{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Li YY"],"pubmed_abstract":["<h4>Introduction</h4>Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.<h4>Methods</h4>TCGA data were analyzed, <i>in vitro</i> and <i>in vivo</i> experiments were performed to assess DLL3 and miR-508-5p function, and bioinformatics was used to confirm their interaction. Mesenchymal stem cells (MSCs) were engineered to produce miR-508-5p-overexpressing exosomes, and their therapeutic effects were tested in mouse models.<h4>Results</h4>Elevated DLL3 and downregulated miR-508-5p were observed in "],"journal":["Frontiers in oncology"],"pagination":["1532564"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11891050"],"repository":["biostudies-literature"],"pubmed_title":["Engineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3."],"pmcid":["PMC11891050"],"pubmed_authors":["Liu H","Feng JL","Tian WY","Du J","Li YY","Zhang LP"],"additional_accession":[]},"is_claimable":false,"name":"Engineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3.","description":"<h4>Introduction</h4>Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.<h4>Methods</h4>TCGA data were analyzed, <i>in vitro</i> and <i>in vivo</i> experiments were performed to assess DLL3 and miR-508-5p function, and bioinformatics was used to confirm their interaction. Mesenchymal stem cells (MSCs) were engineered to produce miR-508-5p-overexpressing exosomes, and their therapeutic effects were tested in mouse models.<h4>Results</h4>Elevated DLL3 and downregulated miR-508-5p were observed in ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-04T08:22:15.161Z","creation":"2025-04-04T08:22:15.161Z"},"accession":"S-EPMC11891050","cross_references":{"pubmed":["40066092"],"doi":["10.3389/fonc.2025.1532564"]}}