biostudies-literatureUnknown15Li YY<h4>Introduction</h4>Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.<h4>Methods</h4>TCGA data were analyzed, <i>in vitro</i> and <i>in vivo</i> experiments were performed to assess DLL3 and miR-508-5p function, and bioinformatics was used to confirm their interaction. Mesenchymal stem cells (MSCs) were engineered to produce miR-508-5p-overexpressing exosomes, and their therapeutic effects were tested in mouse models.<h4>Results</h4>Elevated DLL3 and downregulated miR-508-5p were observed in Frontiers in oncology1532564https://www.ebi.ac.uk/biostudies/studies/S-EPMC11891050biostudies-literatureEngineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3.PMC11891050Liu HFeng JLTian WYDu JLi YYZhang LPfalseEngineered exosomes restore miR-508-5p expression in uterine corpus endometrial carcinoma and reduce tumor progression and metastasis by targeting DLL3.<h4>Introduction</h4>Endometrial cancer (EC) is a growing global health concern. Understanding the molecular mechanisms driving EC is crucial for developing effective diagnostic and therapeutic strategies. This study investigates the roles of DLL3 and miR-508-5p in EC progression and explores a therapeutic approach using engineered exosomes to modulate their expression.<h4>Methods</h4>TCGA data were analyzed, <i>in vitro</i> and <i>in vivo</i> experiments were performed to assess DLL3 and miR-508-5p function, and bioinformatics was used to confirm their interaction. Mesenchymal stem cells (MSCs) were engineered to produce miR-508-5p-overexpressing exosomes, and their therapeutic effects were tested in mouse models.<h4>Results</h4>Elevated DLL3 and downregulated miR-508-5p were observed in 2025-01-01T00:00:00Z20252025-04-04T08:22:15.161Z2025-04-04T08:22:15.161ZS-EPMC118910504006609210.3389/fonc.2025.1532564