{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhen W"],"funding":["Ludwig Institute for Metastasis Research","NCI NIH HHS","National Institutes of Health","University of Chicago Medicine Comprehensive Cancer Center","NIH HHS"],"pagination":["e2405494"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11891090"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(52)"],"pubmed_abstract":["The efficacy of radiotherapy (RT) is limited by inefficient X-ray absorption and reactive oxygen species generation, upregulation of immunosuppressive factors, and a reducing tumor microenvironment (TME). Here, the design of a mitochondria-targeted and digitonin (Dig)-loaded nanoscale metal-organic framework, Th-Ir-DBB/Dig, is reported to overcome these limitations and elicit strong antitumor effects upon low-dose X-ray irradiation. Built from Th<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub> secondary building units (SBUs) and photosensitizing Ir(DBB)(ppy)<sub>2</sub> <sup>2+</sup> (Ir-DBB, DBB = 4,4'-di(4-benzoato)-2,2'-bipyridine; ppy = 2-phenylpyridine) ligands, Th-Ir-DBB exhibits strong RT-radiodynamic therapy (RDT) effects via potent radiosensitization with high-Z SBUs for hydroxyl radical"],"journal":["Advanced materials (Deerfield Beach, Fla.)"],"pubmed_title":["Digitonin-Loaded Nanoscale Metal-Organic Framework for Mitochondria-Targeted Radiotherapy-Radiodynamic Therapy and Disulfidptosis."],"pmcid":["PMC11891090"],"funding_grant_id":["NIH CCSG: P30 CA014599","R01 CA253655","P30 CA014599","1R01CA253655"],"pubmed_authors":["Blenko AL","Germanas T","Zhen W","Li J","Fan Y","Tillman L","Lin W","Weichselbaum RR"],"additional_accession":[]},"is_claimable":false,"name":"Digitonin-Loaded Nanoscale Metal-Organic Framework for Mitochondria-Targeted Radiotherapy-Radiodynamic Therapy and Disulfidptosis.","description":"The efficacy of radiotherapy (RT) is limited by inefficient X-ray absorption and reactive oxygen species generation, upregulation of immunosuppressive factors, and a reducing tumor microenvironment (TME). Here, the design of a mitochondria-targeted and digitonin (Dig)-loaded nanoscale metal-organic framework, Th-Ir-DBB/Dig, is reported to overcome these limitations and elicit strong antitumor effects upon low-dose X-ray irradiation. Built from Th<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub> secondary building units (SBUs) and photosensitizing Ir(DBB)(ppy)<sub>2</sub> <sup>2+</sup> (Ir-DBB, DBB = 4,4'-di(4-benzoato)-2,2'-bipyridine; ppy = 2-phenylpyridine) ligands, Th-Ir-DBB exhibits strong RT-radiodynamic therapy (RDT) effects via potent radiosensitization with high-Z SBUs for hydroxyl radical","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-14T03:09:52.126Z","creation":"2026-06-14T03:08:08.685Z"},"accession":"S-EPMC11891090","cross_references":{"pubmed":["39252688"],"doi":["10.1002/adma.202405494"]}}