biostudies-literatureUnknown11(Suppl 3)Atuhaire P<h4>Background</h4>Low- and middle-income countries lack data on culture-confirmed sepsis in HIV-exposed infants, despite the reported heightened risk of infectious morbidity. This study describes culture-confirmed sepsis and antibiotic resistance patterns among HIV-exposed children in a large etiological cohort study in Kampala, Uganda.<h4>Methods</h4>This was a prospective birth cohort study based at 2 Ugandan sites, as part of the Progressing Group B Streptococcal Vaccines (PROGRESS) study. Any infant with risk factors, signs, or symptoms of infection presenting before 3 months of age had a blood culture and nasopharyngeal swab taken to determine the etiology of neonatal and young infant sepsis.<h4>Results</h4>Among 4492 blood cultures, 460 were obtained from HIV-exposed infants. Nine iOpen forum infectious diseasesS187-S192https://www.ebi.ac.uk/biostudies/studies/S-EPMC11891132biostudies-literatureHIV Exposure and Neonatal Sepsis: A Descriptive Etiological Study.PMC11891132Doare KLKipyeko SNajuka CBeach SHeath PTCochet MPROGRESS Study Author GroupTusubira VPortal EARO'Hara GWamawobe ASeeley JDavies HGAzuba RDjennad AKomugisha CMutabazi TLe Doare KKarampatsas KRavji PNakimuli AShelley DRNamugumya RMusoke PSpiller OBSsali AKarafillakis EFarley CNyamaizi AOwor MNanyunja CPeacock JCowie KSewegaba MChalker VKatungye RVoysey MSekikubo MEtti MMatovu GSendagala JNNalubega PParks RDuckworth EAtuhaire PHookham LOld TKyohere MBentley SAmone AMusooko MfalseHIV Exposure and Neonatal Sepsis: A Descriptive Etiological Study.<h4>Background</h4>Low- and middle-income countries lack data on culture-confirmed sepsis in HIV-exposed infants, despite the reported heightened risk of infectious morbidity. This study describes culture-confirmed sepsis and antibiotic resistance patterns among HIV-exposed children in a large etiological cohort study in Kampala, Uganda.<h4>Methods</h4>This was a prospective birth cohort study based at 2 Ugandan sites, as part of the Progressing Group B Streptococcal Vaccines (PROGRESS) study. Any infant with risk factors, signs, or symptoms of infection presenting before 3 months of age had a blood culture and nasopharyngeal swab taken to determine the etiology of neonatal and young infant sepsis.<h4>Results</h4>Among 4492 blood cultures, 460 were obtained from HIV-exposed infants. Nine i2024-01-01T00:00:00Z2024 Dec2026-05-29T16:50:53.395Z2025-04-07T07:56:38.688ZS-EPMC118911324007069910.1093/ofid/ofae642