biostudies-literatureUnknown16Tilp M<h4>Introduction</h4>There is a well-established relationship between the respiratory compensation point (RCP) and local muscular breakpoints determined from near-infrared spectroscopy (NIRS) and electromyography (EMG). However, these breakpoints have not yet been compared both in locomotor and non-locomotor muscles simultaneously in single-leg cycling exercise. Therefore, the aim of the study was to investigate the relationship and agreement between systemic and local breakpoints in locomotor and non-locomotor muscles.<h4>Method</h4>Data from twelve physically-active participants (25.5 ± 3.9 years, 176.1 ± 11.6 cm, 71.2 ± 9.4 kg, 4 females) who completed a continuous single-leg step incremental cycling test (10 W min^-1) with their right leg were included in the analysis. VentilFrontiers in physiology1465344https://www.ebi.ac.uk/biostudies/studies/S-EPMC11891192biostudies-literatureThe relationship and agreement between systemic and local breakpoints in locomotor and non-locomotor muscles during single-leg cycling.PMC11891192Tschakert GMosser NKruse ATilp MSchappacher-Tilp GBirnbaumer PfalseThe relationship and agreement between systemic and local breakpoints in locomotor and non-locomotor muscles during single-leg cycling.<h4>Introduction</h4>There is a well-established relationship between the respiratory compensation point (RCP) and local muscular breakpoints determined from near-infrared spectroscopy (NIRS) and electromyography (EMG). However, these breakpoints have not yet been compared both in locomotor and non-locomotor muscles simultaneously in single-leg cycling exercise. Therefore, the aim of the study was to investigate the relationship and agreement between systemic and local breakpoints in locomotor and non-locomotor muscles.<h4>Method</h4>Data from twelve physically-active participants (25.5 ± 3.9 years, 176.1 ± 11.6 cm, 71.2 ± 9.4 kg, 4 females) who completed a continuous single-leg step incremental cycling test (10 W min^-1) with their right leg were included in the analysis. Ventil2025-01-01T00:00:00Z20252025-04-04T08:23:09.248Z2025-04-04T08:23:09.248ZS-EPMC118911924006628310.3389/fphys.2025.1465344