{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(9)"],"submitter":["Hu Q"],"pubmed_abstract":["The diagnosis of metastatic and recurrent occult thyroid cancer presents a significant challenge. This study introduces a DNA-Mn hydrogel (M-TDH) that specifically targets thyroglobulin (Tg). This nanogel is loaded with paramagnetic Mn<sup>2+</sup> for facilitating magnetic resonance (MR) imaging. As a cofactor of DNA polymerase, Mn<sup>2+</sup> promotes the extension of long-strand DNA and forms Mn<sub>2</sub>PPi nuclei with PPi<sup>4-</sup> in the system. The synthesis of M-TDH is achieved through Mn<sub>2</sub>PPi nucleation and growth with long-strand DNA acting as the structural framework. The X-scaffold functions as a junction point, thereby enhancing structural stability. The Tg aptamer sequence is incorporated into M-TDH, ensuring specific targeting of thyroid cancer cells. Further"],"journal":["ACS applied materials & interfaces"],"pagination":["13403-13414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11891823"],"repository":["biostudies-literature"],"pubmed_title":["Manganese-Loaded pH-Responsive DNA Hydrogels Enable Tg-Guided Thyroid Tumor Targeted Magnetic Resonance Imaging."],"pmcid":["PMC11891823"],"pubmed_authors":["Tang Z","Liu J","Wang DY","Huang T","Wang R","Zhang X","Hu Q","Ren A","Ming J"],"additional_accession":[]},"is_claimable":false,"name":"Manganese-Loaded pH-Responsive DNA Hydrogels Enable Tg-Guided Thyroid Tumor Targeted Magnetic Resonance Imaging.","description":"The diagnosis of metastatic and recurrent occult thyroid cancer presents a significant challenge. This study introduces a DNA-Mn hydrogel (M-TDH) that specifically targets thyroglobulin (Tg). This nanogel is loaded with paramagnetic Mn<sup>2+</sup> for facilitating magnetic resonance (MR) imaging. As a cofactor of DNA polymerase, Mn<sup>2+</sup> promotes the extension of long-strand DNA and forms Mn<sub>2</sub>PPi nuclei with PPi<sup>4-</sup> in the system. The synthesis of M-TDH is achieved through Mn<sub>2</sub>PPi nucleation and growth with long-strand DNA acting as the structural framework. The X-scaffold functions as a junction point, thereby enhancing structural stability. The Tg aptamer sequence is incorporated into M-TDH, ensuring specific targeting of thyroid cancer cells. Further","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T08:22:34.654Z","creation":"2025-04-04T08:22:34.654Z"},"accession":"S-EPMC11891823","cross_references":{"pubmed":["39996966"],"doi":["10.1021/acsami.4c19676"]}}