biostudies-literatureQian ZGuangdong Basic and Applied Basic Research FoundationNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong Province of ChinaScience and Technology Projects in Guangzhou2474730https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892071biostudies-literatureUnknown57(1)<h4>Background</h4>Previous studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic diseases.<h4>Methods</h4>A total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. <i>Akkermansia</i> abundance in stool sampleAnnals of medicineDecreased intestinal abundance of &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; is associated with metabolic disorders among people living with HIV.PMC118920712023A1515011587KS0120220270]819700122023A04J2398Wu JQian ZCai SLiao XXie JOu LZuo XZhong HChen SXu XPeng JXu YfalseDecreased intestinal abundance of &lt;i&gt;Akkermansia muciniphila&lt;/i&gt; is associated with metabolic disorders among people living with HIV.<h4>Background</h4>Previous studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic diseases.<h4>Methods</h4>A total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. <i>Akkermansia</i> abundance in stool sample2025-01-01T00:00:00Z2025 Dec2026-06-02T19:18:49.19Z2025-04-04T02:51:06.556ZS-EPMC118920714005245010.1080/07853890.2025.2474730