biostudies-literatureZhang CNational Science and Technology Innovation 2030, Major Project- Research on Cancer, Cardiovascular, Respiratory and Metabolic DiseasesNational Natural Science Foundation of China148https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892250biostudies-literatureUnknown23(1)<h4>Background</h4>The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature and its potential correlation with clinical parameters of PH.<h4>Methods</h4>Overall, 244 patients with PH and 120 healthy controls (CON) were recruited from three independent centers. The PH group was divided into subgroups not using antibiotics or corticosteroids (non-ANT/CORT), and those using ANT, CORT, or ANT + CORT within 1 month, and clinical classification (Groups 1, 3, and 4), World Health Organization functional class (I-IV), and disease severity based on mean pulmonary artery pressure or pulmonary vascular resistance levels for in-depth comparison.<h4>Results</h4>Distinct airway mycobiome profiles were observed in PH,BMC medicineDistinct airway mycobiome signature in patients with pulmonary hypertension and subgroups.PMC118922502024ZD052870082241012, 82270052, 82120108001, 82170065, 82170069, 82370063Zheng YZhong BLu WLiang WYang KXing YJiang QLi PLin ZZhao ZWang JWu HHong CLi ZZhang TZhang ZZhang YChen YLiu CZhang CYuan JXWu XfalseDistinct airway mycobiome signature in patients with pulmonary hypertension and subgroups.<h4>Background</h4>The association between lung microbiome and pulmonary hypertension (PH) remain unknown. This study aims to define the airway mycobiome signature and its potential correlation with clinical parameters of PH.<h4>Methods</h4>Overall, 244 patients with PH and 120 healthy controls (CON) were recruited from three independent centers. The PH group was divided into subgroups not using antibiotics or corticosteroids (non-ANT/CORT), and those using ANT, CORT, or ANT + CORT within 1 month, and clinical classification (Groups 1, 3, and 4), World Health Organization functional class (I-IV), and disease severity based on mean pulmonary artery pressure or pulmonary vascular resistance levels for in-depth comparison.<h4>Results</h4>Distinct airway mycobiome profiles were observed in PH,2025-01-01T00:00:00Z2025 Mar2025-04-22T20:48:01.178Z2025-04-06T03:22:03.365ZS-EPMC118922504005913810.1186/s12916-025-03982-7