{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan Y"],"funding":["Key Technologies Research and Development Program","Key Research and Development Projects of Shaanxi Province","National Natural Science Foundation of China"],"pagination":["300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892279"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Background
In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9). Here, we tested the cardio-protective impacts of fCTRP9, gCTRP9, and N-terminal domain, including the variable and collagenous domain, of CTRP9 (nCTRP9) in the context of MI.Methods
Studies comparing the protective properties of fCTRP9 and gCTRP9 against MI in mice hearts were performed both in vitr"],"journal":["Journal of translational medicine"],"pubmed_title":["N-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway."],"pmcid":["PMC11892279"],"funding_grant_id":["2023-ZDLSF-39","82170336","82270286","81870266","2022YFC2402804","82000227"],"pubmed_authors":["Li H","Liu Y","Shi L","Cao G","Zhang Y","Tan Y","Yan D","Li P","Zhang B","Yi W","Sun Y","Xin J"],"additional_accession":[]},"is_claimable":false,"name":"N-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway.","description":"Background
In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9). Here, we tested the cardio-protective impacts of fCTRP9, gCTRP9, and N-terminal domain, including the variable and collagenous domain, of CTRP9 (nCTRP9) in the context of MI.Methods
Studies comparing the protective properties of fCTRP9 and gCTRP9 against MI in mice hearts were performed both in vitr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-26T02:52:27.046Z","creation":"2025-04-06T10:36:02.343Z"},"accession":"S-EPMC11892279","cross_references":{"pubmed":["40065407"],"doi":["10.1186/s12967-025-06274-z"]}}