biostudies-literatureTan YKey Technologies Research and Development ProgramKey Research and Development Projects of Shaanxi ProvinceNational Natural Science Foundation of China300https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892279biostudies-literatureUnknown23(1)<h4>Background</h4>In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9). Here, we tested the cardio-protective impacts of fCTRP9, gCTRP9, and N-terminal domain, including the variable and collagenous domain, of CTRP9 (nCTRP9) in the context of MI.<h4>Methods</h4>Studies comparing the protective properties of fCTRP9 and gCTRP9 against MI in mice hearts were performed both in vitrJournal of translational medicineN-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway.PMC118922792023-ZDLSF-398217033682270286818702662022YFC240280482000227Li HLiu YShi LCao GZhang YTan YYan DLi PZhang BYi WSun YXin JfalseN-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway.<h4>Background</h4>In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9). Here, we tested the cardio-protective impacts of fCTRP9, gCTRP9, and N-terminal domain, including the variable and collagenous domain, of CTRP9 (nCTRP9) in the context of MI.<h4>Methods</h4>Studies comparing the protective properties of fCTRP9 and gCTRP9 against MI in mice hearts were performed both in vitr2025-01-01T00:00:00Z2025 Mar2025-04-26T02:52:27.046Z2025-04-06T10:36:02.343ZS-EPMC118922794006540710.1186/s12967-025-06274-z