biostudies-literatureCorines MJNational Institutes of Health National Cancer InstituteNCI NIH HHSNational Institutes of Health111986https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892329biostudies-literatureUnknown184<h4>Background</h4>We explored the use of MRI T2-weighted imaging (T2WI) radiomics to help distinguish acellular mucin from cellular mucin (residual tumor) to inform patient management.<h4>Methods</h4>This retrospective, multi-institutional study included consecutive patients with rectal adenocarcinoma containing mucin on restaging MRI from March 2012-January 2020. Radiologists segmented 3-mm-thick T2WI. Data were split into training (n = 122), validation (n = 40), and test (n = 42) sets. Sensitivity, specificity, PPV, NPV, and AUC of the developed radiomic models were investigated on the test set. Histopathology was the reference standard. Two radiologists independently reviewed 42 patients using a unique five-point Likert scale for the probability of cellular mucin. DeLong-Delong or McNeEuropean journal of radiologyCan MRI radiomics distinguish residual adenocarcinoma from acellular mucin in treated rectal cancer?PMC11892329P30 CA008748Lee SSheedy SPSchwartz LHZhao BIbrahim AErnst RGollub MJKorngold EMiranda JZheng JHorvat NNougaret SMoreno CCFox MNahas SCBaheti ACorines MJGangai NPetkovska ISosa REGibbs PfalseCan MRI radiomics distinguish residual adenocarcinoma from acellular mucin in treated rectal cancer?<h4>Background</h4>We explored the use of MRI T2-weighted imaging (T2WI) radiomics to help distinguish acellular mucin from cellular mucin (residual tumor) to inform patient management.<h4>Methods</h4>This retrospective, multi-institutional study included consecutive patients with rectal adenocarcinoma containing mucin on restaging MRI from March 2012-January 2020. Radiologists segmented 3-mm-thick T2WI. Data were split into training (n = 122), validation (n = 40), and test (n = 42) sets. Sensitivity, specificity, PPV, NPV, and AUC of the developed radiomic models were investigated on the test set. Histopathology was the reference standard. Two radiologists independently reviewed 42 patients using a unique five-point Likert scale for the probability of cellular mucin. DeLong-Delong or McNe2025-01-01T00:00:00Z2025 Mar2026-07-16T23:39:03.802Z2026-07-12T03:11:44.219ZS-EPMC118923293992359410.1016/j.ejrad.2025.111986