biostudies-literatureBhatt SPNIA NIH HHSNHLBI NIH HHSNIMHD NIH HHSNINR NIH HHSNIHNIH HHS359-366https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892675biostudies-literatureUnknown22(3)<b>Rationale:</b> Chronic lung diseases are associated with increased risk of mortality due to coronary heart disease (CHD). Nonetheless, the population attributable fraction (PAF) of lung function impairment relative to other established cardiovascular risk factors is unclear. <b>Objectives:</b> To evaluate the PAF of low lung function for CHD mortality <b>Methods:</b> We harmonized and pooled lung function and clinical data across eight U.S. general population cohorts. Impaired lung function was defined as forced expiratory volume in 1 second (FEV₁) and/or forced vital capacity ≤ 95% predicted on baseline spirometry. The association between CHD mortality and risk factors was assessed using cause-specific proportional hazards and Fine-Gray proportional subdistribution hazard moAnnals of the American Thoracic SocietyLow Lung Function Is Associated with High Population Attributable Fraction for Cardiovascular Mortality.PMC11892675N01 HC085083N01 HC085082N01 HC085081RC1 HL100543R01 HL109301N01 HC085086N01 HC095166HHSN268201700004IN01 HC095165N01 HC095168N01 HC095167N01 HC085080HHSN268201800014CN01 HC095169U01 HL065520U01 HL065521N01 HC095160R01 AG023629N01 HC095162N01 HC095161N01 HC095164HHSN268201800014IN01 HC095163HHSN268201700004CHHSN268201800010IHHSN268201500001CR21 HL156228HHSN268201700003IR01 NR012459HHSN268200800007CN01 HC055222U01 HL041642HHSN268201800001CHHSN268201700003CHHSN268201800013IR21 HL165405HHSN268201500001IR01 HL151421R01 AG028050U01 HL080295R01 HL109284R01 HL109282HHSN268201700002IU01 HL041652N01 HC025195U01 HL041654HHSN268201800012CK23 HL130627HHSN268201200036CHHSN268201800012IHHSN268201700002CR01 HL157634R01 HL155576R01 HL109315R21 HL12992475N92023D00004R01 HL07761275N92023D00005R01 HL09308175N92023D0000675N92023D00002HHSN268201700005I75N92023D00003N01 HC095159HHSN268201700001IHHSN268201700005CHHSN268201800015IHHSN268201800011CHHSN268201700001CHHSN268201800011IN01 HC085079UH3 HL155806R01 HL109319U01 HL130114Schwartz JEBalte PPO'Connor GTWu CSun YJaeger BCOelsner ECWhite WBChaves PHBhatt SPLloyd-Jones DKalhan RYende SNewman ABDivo MJCouper DUmans JGJacobs DRfalseLow Lung Function Is Associated with High Population Attributable Fraction for Cardiovascular Mortality.<b>Rationale:</b> Chronic lung diseases are associated with increased risk of mortality due to coronary heart disease (CHD). Nonetheless, the population attributable fraction (PAF) of lung function impairment relative to other established cardiovascular risk factors is unclear. <b>Objectives:</b> To evaluate the PAF of low lung function for CHD mortality <b>Methods:</b> We harmonized and pooled lung function and clinical data across eight U.S. general population cohorts. Impaired lung function was defined as forced expiratory volume in 1 second (FEV₁) and/or forced vital capacity ≤ 95% predicted on baseline spirometry. The association between CHD mortality and risk factors was assessed using cause-specific proportional hazards and Fine-Gray proportional subdistribution hazard mo2025-01-01T00:00:00Z2025 Mar2026-07-16T23:28:51.502Z2026-07-12T03:11:17.708ZS-EPMC118926753944711510.1513/AnnalsATS.202407-715OC10.1513/annalsats.202407-715oc