{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Varady A"],"funding":["Österreichische Forschungsförderungsgesellschaft","Austrian Science Fund FWF","Alex's Lemonade Stand Foundation for Childhood Cancer","Österreichischen Akademie der Wissenschaften","St. Anna Children's Cancer Research Institute"],"pagination":["DMM052016"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Owing to their high efficacy, antimitotic chemotherapeutics are the mainstay for most cancer treatments. However, these drugs do not discriminate between tumor and healthy cells, thus show dose-limiting toxicity and severe adverse effects. To improve treatments, rendering chemotherapeutics tumor-cell specific is highly desirable. Although various strategies, such as targeted antibody-drug conjugates, aim to achieve this goal, the identification of a tumor-specific 'Achilles' heel' remains a challenge. Here, we followed an alternative approach, which does not rely on tumor-specific characteristics, but rather uses spatially confined illumination of the light-activatable microtubule inhibitor SBTubA4P to target its cytotoxic activity to tumor cells. We demonstrate that localized illumination"],"journal":["Disease models & mechanisms"],"pubmed_title":["Precise photopharmacological eradication of metastatic tumor cells."],"pmcid":["PMC11892682"],"funding_grant_id":["7940628","20-17258","P30038-BBL"],"pubmed_authors":["Varady A","Schmitner N","Poplimont H","Sturtzel C","Gao L","Distel M","Kimmel RA","Grissenberger S","Wenninger-Weinzierl A"],"additional_accession":[]},"is_claimable":false,"name":"Precise photopharmacological eradication of metastatic tumor cells.","description":"Owing to their high efficacy, antimitotic chemotherapeutics are the mainstay for most cancer treatments. However, these drugs do not discriminate between tumor and healthy cells, thus show dose-limiting toxicity and severe adverse effects. To improve treatments, rendering chemotherapeutics tumor-cell specific is highly desirable. Although various strategies, such as targeted antibody-drug conjugates, aim to achieve this goal, the identification of a tumor-specific 'Achilles' heel' remains a challenge. Here, we followed an alternative approach, which does not rely on tumor-specific characteristics, but rather uses spatially confined illumination of the light-activatable microtubule inhibitor SBTubA4P to target its cytotoxic activity to tumor cells. We demonstrate that localized illumination","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-29T12:46:29.662Z","creation":"2025-04-05T23:53:16.938Z"},"accession":"S-EPMC11892682","cross_references":{"pubmed":["40014051"],"doi":["10.1242/dmm.052016"]}}