{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(3)"],"submitter":["Zhao J"],"pubmed_abstract":["Exploring the possibility of familiar dietary sources as additional diabetes treatments is crucial, especially considering the financial difficulties related to diabetes mellitus. Using both in vitro and in silico techniques, this work aims to assess the antidiabetic benefits of extract from Solanum lasiocarpum Dunal. The evaluations encompass the ability to scavenge DPPH radicals, inhibition of α-amylase, α-glucosidase, inhibition of DPP-4, cytotoxicity, and glucose absorption kinetics. With an IC50 value of 0.69 ±  0.14 mg/ml, S. lasiocarpum showed encouraging DPPH inhibition. IC50 values of 2.123 ±  0.14 mg/ml inhibited the enzymes α-amylase, α-glucosidase, and DPP-4. Furthermore, a notable increase (P < 0.05) in glucose uptake by L6 myoblasts was observed with the administration of var"],"journal":["PloS one"],"pagination":["e0312600"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11892833"],"repository":["biostudies-literature"],"pubmed_title":["In Vitro and In Silico Antidiabetic Efficacy of Solanum lasiocarpum Dunal Fruit Extract."],"pmcid":["PMC11892833"],"pubmed_authors":["Ming ZY","Talib WH","Najm AA","Dutta PP","Law D","Mahmood I","Zhao J","Fazry S"],"additional_accession":[]},"is_claimable":false,"name":"In Vitro and In Silico Antidiabetic Efficacy of Solanum lasiocarpum Dunal Fruit Extract.","description":"Exploring the possibility of familiar dietary sources as additional diabetes treatments is crucial, especially considering the financial difficulties related to diabetes mellitus. Using both in vitro and in silico techniques, this work aims to assess the antidiabetic benefits of extract from Solanum lasiocarpum Dunal. The evaluations encompass the ability to scavenge DPPH radicals, inhibition of α-amylase, α-glucosidase, inhibition of DPP-4, cytotoxicity, and glucose absorption kinetics. With an IC50 value of 0.69 ±  0.14 mg/ml, S. lasiocarpum showed encouraging DPPH inhibition. IC50 values of 2.123 ±  0.14 mg/ml inhibited the enzymes α-amylase, α-glucosidase, and DPP-4. Furthermore, a notable increase (P < 0.05) in glucose uptake by L6 myoblasts was observed with the administration of var","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T04:43:02.776Z","creation":"2025-04-06T22:13:37.077Z"},"accession":"S-EPMC11892833","cross_references":{"pubmed":["40063647"],"doi":["10.1371/journal.pone.0312600"]}}