biostudies-literatureTian YNational Heart, Lung, and Blood InstituteNHLBI NIH HHSDivision of Computer and Network Systems1999-2007https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893024biostudies-literatureUnknown93(5)<h4>Purpose</h4>To develop a robust single breath-hold approach for volumetric lung imaging at 0.55T.<h4>Method</h4>A balanced-SSFP (bSSFP) pulse sequence with 3D stack-of-spiral (SoS) out-in trajectory for volumetric lung imaging at 0.55T was implemented. With 2.7× undersampling, the pulse sequence enables imaging during a 17-s breath-hold. Image reconstruction is performed using 3D SPIRiT and 3D l1-Wavelet regularizations. In two healthy volunteers, single breath-hold SoS out-in bSSFP was compared against stack-of-spiral UTE (spiral UTE) and half-radial dual-echo bSSFP (bSTAR), based on signal intensity (SI), blood-lung parenchyma contrast, and image quality. In six patients with pathologies including lung nodules, fibrosis, emphysema, and air trapping, single breath-hold SoS out-in and Magnetic resonance in medicineSingle breath-hold volumetric lung imaging at 0.55T using stack-of-spiral (SoS) out-in balanced SSFP.PMC11893024R21HL1595331828736U01HL167613U01 HL167613Nayak KSLee NGWilcox AGNieva JJTian YZhao ZfalseSingle breath-hold volumetric lung imaging at 0.55T using stack-of-spiral (SoS) out-in balanced SSFP.<h4>Purpose</h4>To develop a robust single breath-hold approach for volumetric lung imaging at 0.55T.<h4>Method</h4>A balanced-SSFP (bSSFP) pulse sequence with 3D stack-of-spiral (SoS) out-in trajectory for volumetric lung imaging at 0.55T was implemented. With 2.7× undersampling, the pulse sequence enables imaging during a 17-s breath-hold. Image reconstruction is performed using 3D SPIRiT and 3D l1-Wavelet regularizations. In two healthy volunteers, single breath-hold SoS out-in bSSFP was compared against stack-of-spiral UTE (spiral UTE) and half-radial dual-echo bSSFP (bSTAR), based on signal intensity (SI), blood-lung parenchyma contrast, and image quality. In six patients with pathologies including lung nodules, fibrosis, emphysema, and air trapping, single breath-hold SoS out-in and 2025-01-01T00:00:00Z2025 May2025-04-04T02:21:56.369Z2025-04-04T02:21:56.369ZS-EPMC118930243960789610.1002/mrm.30386