{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31"],"submitter":["Yu H"],"funding":["Wenzhou Municipal Science and Technology Bureau","Zhejiang Provincial Health Commission"],"pubmed_abstract":["Diabetic wounds often exhibit delayed healing due to compromised vascular function and intensified inflammation. In this study, we overexpressed Thymosin β4 (Tβ4) in Adipose-Derived Stem Cells (ADSCs) to produce Exosomes (Exos) rich in Tβ4. We then utilized a dual photopolymerizable hydrogel composed of Hyaluronic Acid Methacryloyl (HAMA) and Poly-L-lysine Methacryloyl (PLMA) for the sustained release of Tβ4-Exos on diabetic wounds. The results showed that Tβ4-Exos could stimulate angiogenesis and collagen synthesis, and mitigate inflammation in diabetic wounds by promoting the polarization of M1-type macrophages and inhibiting that of M2-type macrophages. Furthermore, Tβ4-Exos was found to activate the PI3K/AKT/mTOR/HIF-1a signaling pathway, thereby enhancing vascular proliferation. In su"],"journal":["Materials today. Bio"],"pagination":["101585"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893380"],"repository":["biostudies-literature"],"pubmed_title":["Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment."],"pmcid":["PMC11893380"],"pubmed_authors":["Liu K","Zhang D","Wang B","Wang G","Chen H","Zhou Y","Wang J","Li L","Yu H","Lai Y","Li Z","Zhao S","Wang Q","He Y","Pan C","Chen W","Ni B","Chen Y"],"additional_accession":[]},"is_claimable":false,"name":"Tβ4-exosome-loaded hemostatic and antibacterial hydrogel to improve vascular regeneration and modulate macrophage polarization for diabetic wound treatment.","description":"Diabetic wounds often exhibit delayed healing due to compromised vascular function and intensified inflammation. In this study, we overexpressed Thymosin β4 (Tβ4) in Adipose-Derived Stem Cells (ADSCs) to produce Exosomes (Exos) rich in Tβ4. We then utilized a dual photopolymerizable hydrogel composed of Hyaluronic Acid Methacryloyl (HAMA) and Poly-L-lysine Methacryloyl (PLMA) for the sustained release of Tβ4-Exos on diabetic wounds. The results showed that Tβ4-Exos could stimulate angiogenesis and collagen synthesis, and mitigate inflammation in diabetic wounds by promoting the polarization of M1-type macrophages and inhibiting that of M2-type macrophages. Furthermore, Tβ4-Exos was found to activate the PI3K/AKT/mTOR/HIF-1a signaling pathway, thereby enhancing vascular proliferation. In su","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-04-26T02:50:08.112Z","creation":"2025-04-06T10:34:57.827Z"},"accession":"S-EPMC11893380","cross_references":{"pubmed":["40070869"],"doi":["10.1016/j.mtbio.2025.101585"]}}