biostudies-literatureUnknown16Li H<h4>Background</h4>Although there is an interaction between sex, body fat distribution, and cardiac structure and function, these relationships have not been fully elucidated yet. This study aims to reveal the causal relationship between genetic determinants of fat distribution pattern and function of the left ventricular structure in different sexes.<h4>Methods</h4>Genetic variants for waist circumference, hip circumference, waist-to-hip ratio (WHR), and body mass index (BMI) were selected from genome-wide association studies conducted in European samples. The dataset for left ventricular (LV) parameters was obtained from over 35,000 European samples in the UK Biobank Cardiovascular Magnetic Resonance sub-study. Two-sample Mendelian randomization (MR) analysis was employed to explore causFrontiers in endocrinology1355968https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893391biostudies-literatureEffect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study.PMC11893391Li HYin GLv FZhang YQin JLi RWang ZYe XfalseEffect of fat distribution on left ventricular structure and function in different sexes: a Mendelian randomization study.<h4>Background</h4>Although there is an interaction between sex, body fat distribution, and cardiac structure and function, these relationships have not been fully elucidated yet. This study aims to reveal the causal relationship between genetic determinants of fat distribution pattern and function of the left ventricular structure in different sexes.<h4>Methods</h4>Genetic variants for waist circumference, hip circumference, waist-to-hip ratio (WHR), and body mass index (BMI) were selected from genome-wide association studies conducted in European samples. The dataset for left ventricular (LV) parameters was obtained from over 35,000 European samples in the UK Biobank Cardiovascular Magnetic Resonance sub-study. Two-sample Mendelian randomization (MR) analysis was employed to explore caus2025-01-01T00:00:00Z20252025-04-26T02:46:45.345Z2025-04-06T10:34:14.948ZS-EPMC118933914007058210.3389/fendo.2025.1355968