biostudies-literatureAzegami TMinistry of Health, Labour and WelfareMinistry of Education, Culture, Sports, Science and Technology, Japanzsae302https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893532biostudies-literatureUnknown48(3)<h4>Study objectives</h4>Sleep apnea syndrome (SAS) is potentially linked to life-threatening conditions. The decline in kidney function is involved in the development of various diseases; however, it remains unclear whether it is implicated in the onset of SAS. Therefore, this study aimed to investigate the relationship between kidney function and the incidence of SAS.<h4>Methods</h4>The association of estimated glomerular filtration rate (eGFR) with the incidence of SAS was assessed retrospectively using real-world administrative claims and health checkup data collected between April 2014 and November 2022. To strengthen robustness, three stratified analyses and four sensitivity analyses were conducted.<h4>Results</h4>We assessed 1 589 259 individuals for the analysis. During a median (iSleepAssociation of estimated glomerular filtration rate with the incidence of sleep apnea syndrome.PMC1189353221K0812320H0390721H0315923AA2003Fujiu KHayashi KTakeda NKaneko HAzegami TYokoo TSuzuki YNangaku MMorita HOkada AKo TYasunaga HfalseAssociation of estimated glomerular filtration rate with the incidence of sleep apnea syndrome.<h4>Study objectives</h4>Sleep apnea syndrome (SAS) is potentially linked to life-threatening conditions. The decline in kidney function is involved in the development of various diseases; however, it remains unclear whether it is implicated in the onset of SAS. Therefore, this study aimed to investigate the relationship between kidney function and the incidence of SAS.<h4>Methods</h4>The association of estimated glomerular filtration rate (eGFR) with the incidence of SAS was assessed retrospectively using real-world administrative claims and health checkup data collected between April 2014 and November 2022. To strengthen robustness, three stratified analyses and four sensitivity analyses were conducted.<h4>Results</h4>We assessed 1 589 259 individuals for the analysis. During a median (i2025-01-01T00:00:00Z2025 Mar2025-04-22T11:17:40.599Z2025-04-05T23:53:58.069ZS-EPMC118935323970449610.1093/sleep/zsae302