biostudies-literatureUnknown16Wang X<h4>Objective</h4>Both B-cell- and T-cell-mediated immunity are crucial for the effective clearance of viral infection, but little is known about the dynamic characteristics of SARS-CoV-2-specific B-cell and T-cell responses in people living with HIV (PLWH) after a full course of inactivated SARS-CoV-2 vaccination.<h4>Methods</h4>In this study, fifty people living with HIV (PLWH) and thirty healthy controls (HCs) were enrolled to assess B-cell and T-cell responses at the day before the vaccination (T0), two weeks after the first dose (T1), two months after the first dose (T2), the day of the third dose (T3), one month after the third dose (T4), three months after the third dose (T5) and 12 months (T6) after the third dose.<h4>Results</h4>SARS-CoV-2-specific B-cell and T-cell responses wereFrontiers in immunology1554409https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893571biostudies-literatureDynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine.PMC11893571Duan JZhang GSu BMa ZZhu AWu HYang XLi YHuang TZhang TJin CZhang XWang XSong XYan HJin JfalseDynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine.<h4>Objective</h4>Both B-cell- and T-cell-mediated immunity are crucial for the effective clearance of viral infection, but little is known about the dynamic characteristics of SARS-CoV-2-specific B-cell and T-cell responses in people living with HIV (PLWH) after a full course of inactivated SARS-CoV-2 vaccination.<h4>Methods</h4>In this study, fifty people living with HIV (PLWH) and thirty healthy controls (HCs) were enrolled to assess B-cell and T-cell responses at the day before the vaccination (T0), two weeks after the first dose (T1), two months after the first dose (T2), the day of the third dose (T3), one month after the third dose (T4), three months after the third dose (T5) and 12 months (T6) after the third dose.<h4>Results</h4>SARS-CoV-2-specific B-cell and T-cell responses were2025-01-01T00:00:00Z20252025-04-20T01:48:02.098Z2025-04-20T01:48:02.098ZS-EPMC118935714007083410.3389/fimmu.2025.1554409