biostudies-literatureUnknown14(1)Kim AR<h4>Introduction</h4>Clinical trial evidence supports early low-density lipoprotein cholesterol (LDL-C) goal achievement in patients with atherosclerotic cardiovascular disease (ASCVD), but real-world evidence in Asia is lacking. We investigated the effects of early LDL-C goal achievement on recurrent major cardiovascular events (MACEs) among patients with very-high-risk ASCVD in South Korea.<h4>Methods</h4>We included adult patients hospitalized with ASCVD (acute coronary syndrome [ACS], stable angina, ischemic stroke, transient ischemic attack, peripheral arterial disease, or asymptomatic coronary artery disease) at a major Korean tertiary hospital from 2000 to 2020. Patients were categorized into early or non-early target LDL-C groups based on LDL-C measured 4-12 weeks post-discharge (<Cardiology and therapy101-115https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893916biostudies-literatureCardiovascular Outcomes of Early LDL-C Goal Achievement in Patients with Very-High-Risk ASCVD.PMC11893916Kang HJKwon SUKwon OLee HBaek YHKim MAhn IKim YHKim AROh JSKim JHJun TJHan JYfalseCardiovascular Outcomes of Early LDL-C Goal Achievement in Patients with Very-High-Risk ASCVD.<h4>Introduction</h4>Clinical trial evidence supports early low-density lipoprotein cholesterol (LDL-C) goal achievement in patients with atherosclerotic cardiovascular disease (ASCVD), but real-world evidence in Asia is lacking. We investigated the effects of early LDL-C goal achievement on recurrent major cardiovascular events (MACEs) among patients with very-high-risk ASCVD in South Korea.<h4>Methods</h4>We included adult patients hospitalized with ASCVD (acute coronary syndrome [ACS], stable angina, ischemic stroke, transient ischemic attack, peripheral arterial disease, or asymptomatic coronary artery disease) at a major Korean tertiary hospital from 2000 to 2020. Patients were categorized into early or non-early target LDL-C groups based on LDL-C measured 4-12 weeks post-discharge (<2025-01-01T00:00:00Z2025 Mar2025-04-22T11:19:51.333Z2025-04-05T23:54:33.496ZS-EPMC118939163998870410.1007/s40119-025-00397-6