{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Immormino RM"],"funding":["The Arthur and Kayla Spector Charitable Fund","Thurston Arthritis Research Center","2020 American Association of Allergy, Asthma, and Immunology Foundation","NIH HHS"],"pagination":["vlaf008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11893976"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["Whether epigenetic factor UTX, a histone H3 lysine 27 (H3K27) demethylase, is critical for type 2 immunity, including allergic sensitization and antigen-driven anaphylaxis, is unclear. We used UTXfl/fl x Lck-Cre mice with UTX-deficient T cells (UTX-TCD) to determine whether T cell-specific UTX expression regulates antigen-specific IgE production after airway sensitization to peanut and anaphylaxis following intraperitoneal (i.p.) peanut challenge. UTX-TCD mice sensitized via the airway with peanut and lipopolysaccharide (LPS), a bacterial component and environmental adjuvant found in house dust, made 2-fold less peanut-IgE and 3.5-fold less peanut-IgG1 than comparably sensitized UTXfl/fl mice, despite higher total IgE and total IgG1 serum antibody levels pre-sensitization. Peanut-induced a"],"journal":["ImmunoHorizons"],"pubmed_title":["Deficiency of H3K27 histone demethylase UTX in T cells blunts allergic sensitization and anaphylaxis to peanut."],"pmcid":["PMC11893976"],"funding_grant_id":["K08AI141691","R01 ES032544"],"pubmed_authors":["Kulis MD","Iweala OI","Immormino RM","Zhang Y","Kesselring J","Carson AS","Kapita CM","Smeekens J","Wang Y","Thomas KO","Moran TP"],"additional_accession":[]},"is_claimable":false,"name":"Deficiency of H3K27 histone demethylase UTX in T cells blunts allergic sensitization and anaphylaxis to peanut.","description":"Whether epigenetic factor UTX, a histone H3 lysine 27 (H3K27) demethylase, is critical for type 2 immunity, including allergic sensitization and antigen-driven anaphylaxis, is unclear. We used UTXfl/fl x Lck-Cre mice with UTX-deficient T cells (UTX-TCD) to determine whether T cell-specific UTX expression regulates antigen-specific IgE production after airway sensitization to peanut and anaphylaxis following intraperitoneal (i.p.) peanut challenge. UTX-TCD mice sensitized via the airway with peanut and lipopolysaccharide (LPS), a bacterial component and environmental adjuvant found in house dust, made 2-fold less peanut-IgE and 3.5-fold less peanut-IgG1 than comparably sensitized UTXfl/fl mice, despite higher total IgE and total IgG1 serum antibody levels pre-sensitization. Peanut-induced a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-06T22:38:10.514Z","creation":"2025-04-04T02:54:10.111Z"},"accession":"S-EPMC11893976","cross_references":{"pubmed":["40065718"],"doi":["10.1093/immhor/vlaf008"]}}