{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Inoue H"],"pubmed_abstract":["The advent of immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway has revolutionized cancer treatment, resulting in improved clinical outcomes. However, resistance remains a critical challenge. This study aimed to comparatively elucidate immunophenotypic changes in syngeneic mouse models sensitive (MC-38) or resistant (LLC1) to anti-PD-1 monoclonal antibody (mAb) treatment. In the sensitive MC-38 model, anti-PD-1 therapy increased dendritic cells (DCs) and macrophages, while decreasing myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. Enhanced expression of antigen presentation molecules (MHC I/II) and costimulatory molecules (CD80/CD86) was observed on tumor-associated DCs and macrophages. Tumor-infiltrating CD4<sup>+</sup>T, CD8<sup>+</sup>T, regulator"],"journal":["Scientific reports"],"pagination":["8311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894063"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model."],"pmcid":["PMC11894063"],"pubmed_authors":["Ebi N","Fujita M","Hamasaki T","Nakao A","Minomo H","Inoue K","Nagata I","Inoue H","Horai N"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model.","description":"The advent of immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway has revolutionized cancer treatment, resulting in improved clinical outcomes. However, resistance remains a critical challenge. This study aimed to comparatively elucidate immunophenotypic changes in syngeneic mouse models sensitive (MC-38) or resistant (LLC1) to anti-PD-1 monoclonal antibody (mAb) treatment. In the sensitive MC-38 model, anti-PD-1 therapy increased dendritic cells (DCs) and macrophages, while decreasing myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. Enhanced expression of antigen presentation molecules (MHC I/II) and costimulatory molecules (CD80/CD86) was observed on tumor-associated DCs and macrophages. Tumor-infiltrating CD4<sup>+</sup>T, CD8<sup>+</sup>T, regulator","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T20:26:00.244Z","creation":"2025-04-04T20:26:00.244Z"},"accession":"S-EPMC11894063","cross_references":{"pubmed":["40064915"],"doi":["10.1038/s41598-025-91979-w"]}}