{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hurst JH"],"funding":["NIAID NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)"],"pagination":["2383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894178"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Age is among the strongest risk factors for severe outcomes from SARS-CoV-2 infection. Here we describe upper respiratory tract (URT) and peripheral blood transcriptomes of 202 participants (age range of 1 week to 83 years), including 137 non-hospitalized individuals with mild SARS-CoV-2 infection and 65 healthy individuals. Among healthy children and adolescents, younger age is associated with higher URT expression of innate and adaptive immune pathways. SARS-CoV-2 infection induces broad upregulation of URT innate and adaptive immune responses among children and adolescents. Peripheral blood responses among SARS-CoV-2-infected children and adolescents are dominated by interferon pathways, while upregulation of myeloid activation, inflammatory, and coagulation pathways is observed only in"],"journal":["Nature communications"],"pubmed_title":["Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection."],"pmcid":["PMC11894178"],"funding_grant_id":["R01-AI161008, K23-AI135090, K23-AI135090","K01 AI173398"],"pubmed_authors":["Mohan AA","Henao R","Kelly MS","Hurst JH","Rodriguez J","Lugo DJ","Ramilo O","Burke TW","Mejias A","DeMarco CT","Louzao R","Aquino JN","Turner NA","Woods CW","Walsh KM","Rotta AT","Dalapati T","Pfeiffer TS","McClain MT","Denny TN","George IA","Xu Z"],"additional_accession":[]},"is_claimable":false,"name":"Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.","description":"Age is among the strongest risk factors for severe outcomes from SARS-CoV-2 infection. Here we describe upper respiratory tract (URT) and peripheral blood transcriptomes of 202 participants (age range of 1 week to 83 years), including 137 non-hospitalized individuals with mild SARS-CoV-2 infection and 65 healthy individuals. Among healthy children and adolescents, younger age is associated with higher URT expression of innate and adaptive immune pathways. SARS-CoV-2 infection induces broad upregulation of URT innate and adaptive immune responses among children and adolescents. Peripheral blood responses among SARS-CoV-2-infected children and adolescents are dominated by interferon pathways, while upregulation of myeloid activation, inflammatory, and coagulation pathways is observed only in","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-26T02:47:29.917Z","creation":"2025-04-06T10:34:22.365Z"},"accession":"S-EPMC11894178","cross_references":{"pubmed":["40064870"],"doi":["10.1038/s41467-025-57655-3"]}}