{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Ivanova A"],"pubmed_abstract":["There is considerable evidence for a role for metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer's disease (AD). Purine nucleotide synthesis in the brain is regulated with high fidelity to co-ordinate supply with demand. The assembly of some purine biosynthetic enzymes into linear filamentous aggregates called \"cytoophidia\" (Gk. Cellular \"snakes\") represents one post-translational mechanism to regulate enzyme activity. Cytoophidia comprised of the nucleotide biosynthetic enzymes inosine monophosphate dehydrogenase (IMPDH) and phosphoribosyl pyrophosphate synthetase (PRPS) have been described in neuronal nuclei (nuclear cytoophidia; NCs). In light of the involvement of purine nucleotide dysmetabolism in AD, the rationale for this stu"],"journal":["Free neuropathology"],"pagination":["8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894473"],"repository":["biostudies-literature"],"pubmed_title":["Depletion of nuclear cytoophidia in Alzheimer's disease."],"pmcid":["PMC11894473"],"pubmed_authors":["Ivanova A","Woulfe J","Munoz DG"],"additional_accession":[]},"is_claimable":false,"name":"Depletion of nuclear cytoophidia in Alzheimer's disease.","description":"There is considerable evidence for a role for metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer's disease (AD). Purine nucleotide synthesis in the brain is regulated with high fidelity to co-ordinate supply with demand. The assembly of some purine biosynthetic enzymes into linear filamentous aggregates called \"cytoophidia\" (Gk. Cellular \"snakes\") represents one post-translational mechanism to regulate enzyme activity. Cytoophidia comprised of the nucleotide biosynthetic enzymes inosine monophosphate dehydrogenase (IMPDH) and phosphoribosyl pyrophosphate synthetase (PRPS) have been described in neuronal nuclei (nuclear cytoophidia; NCs). In light of the involvement of purine nucleotide dysmetabolism in AD, the rationale for this stu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-04-08T15:40:58.23Z","creation":"2025-04-20T01:46:47.578Z"},"accession":"S-EPMC11894473","cross_references":{"pubmed":["40070795"],"doi":["10.17879/freeneuropathology-2025-6282"]}}