biostudies-literatureBen-Zion ZNIMH NIH HHSe250331https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894499biostudies-literatureUnknown8(3)<h4>Importance</h4>The weak link between subjective symptom-based diagnostics for posttraumatic psychopathology and objective neurobiological indices hinders the development of effective personalized treatments.<h4>Objective</h4>To identify early neural networks associated with posttraumatic stress disorder (PTSD) development among recent trauma survivors.<h4>Design, setting, and participants</h4>This prognostic study used data from the Neurobehavioral Moderators of Posttraumatic Disease Trajectories (NMPTDT) large-scale longitudinal neuroimaging dataset of recent trauma survivors. The NMPTDT study was conducted from January 20, 2015, to March 11, 2020, and included adult civilians who were admitted to a general hospital emergency department in Israel and screened for early PTSD symptoms iJAMA network openConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors.PMC11894499R01 MH103287Shalev AYBen-Zion ZLevy IHendler TScheinost DKorem NLiberzon IHarpaz-Rotem ISimon AJRosenblatt MDuek OfalseConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors.<h4>Importance</h4>The weak link between subjective symptom-based diagnostics for posttraumatic psychopathology and objective neurobiological indices hinders the development of effective personalized treatments.<h4>Objective</h4>To identify early neural networks associated with posttraumatic stress disorder (PTSD) development among recent trauma survivors.<h4>Design, setting, and participants</h4>This prognostic study used data from the Neurobehavioral Moderators of Posttraumatic Disease Trajectories (NMPTDT) large-scale longitudinal neuroimaging dataset of recent trauma survivors. The NMPTDT study was conducted from January 20, 2015, to March 11, 2020, and included adult civilians who were admitted to a general hospital emergency department in Israel and screened for early PTSD symptoms i2025-01-01T00:00:00Z2025 Mar2026-06-01T18:02:14.907Z2025-04-04T00:21:48.225ZS-EPMC118944994006302810.1001/jamanetworkopen.2025.0331