{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["90(9)"],"submitter":["Jankovic D"],"pubmed_abstract":["A complete reduction of alkynes using a combination of [RuCl<sub>2</sub>(<i>p</i>-cymene)]<sub>2</sub>, DTBM-SEGPHOS, and a paraformaldehyde/water system as the hydrogen source was developed, affording alkanes in 52-99% yields. In addition, the preparation of alkenes from terminal alkynes and aryl iodides by a tandem process of Pd/Cu-catalyzed Sonogashira reaction followed by Ru-catalyzed transfer hydrogenation is reported, affording alkenes in 38-99% yields. This multicatalysis proceeds via three consecutive reactions and can be extended further, as shown by adding an iodine-catalyzed <i>cis</i>-<i>trans</i> alkene isomerization step."],"journal":["The Journal of organic chemistry"],"pagination":["3480-3484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894645"],"repository":["biostudies-literature"],"pubmed_title":["Ruthenium-Catalyzed Transfer Hydrogenation of Alkynes: Access to Alkanes and (&lt;i&gt;E&lt;/i&gt;)- or (&lt;i&gt;Z&lt;/i&gt;)-Alkenes in Tandem with Pd/Cu Sonogashira Cross-Coupling."],"pmcid":["PMC11894645"],"pubmed_authors":["Jankovic D","Kosmrlj J","Gazvoda M"],"additional_accession":[]},"is_claimable":false,"name":"Ruthenium-Catalyzed Transfer Hydrogenation of Alkynes: Access to Alkanes and (&lt;i&gt;E&lt;/i&gt;)- or (&lt;i&gt;Z&lt;/i&gt;)-Alkenes in Tandem with Pd/Cu Sonogashira Cross-Coupling.","description":"A complete reduction of alkynes using a combination of [RuCl<sub>2</sub>(<i>p</i>-cymene)]<sub>2</sub>, DTBM-SEGPHOS, and a paraformaldehyde/water system as the hydrogen source was developed, affording alkanes in 52-99% yields. In addition, the preparation of alkenes from terminal alkynes and aryl iodides by a tandem process of Pd/Cu-catalyzed Sonogashira reaction followed by Ru-catalyzed transfer hydrogenation is reported, affording alkenes in 38-99% yields. This multicatalysis proceeds via three consecutive reactions and can be extended further, as shown by adding an iodine-catalyzed <i>cis</i>-<i>trans</i> alkene isomerization step.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T01:13:08.072Z","creation":"2025-04-04T01:13:08.072Z"},"accession":"S-EPMC11894645","cross_references":{"pubmed":["40013586"],"doi":["10.1021/acs.joc.4c01864"]}}