biostudies-literatureUnknown90(9)Jankovic DA complete reduction of alkynes using a combination of [RuCl<sub>2</sub>(<i>p</i>-cymene)]<sub>2</sub>, DTBM-SEGPHOS, and a paraformaldehyde/water system as the hydrogen source was developed, affording alkanes in 52-99% yields. In addition, the preparation of alkenes from terminal alkynes and aryl iodides by a tandem process of Pd/Cu-catalyzed Sonogashira reaction followed by Ru-catalyzed transfer hydrogenation is reported, affording alkenes in 38-99% yields. This multicatalysis proceeds via three consecutive reactions and can be extended further, as shown by adding an iodine-catalyzed <i>cis</i>-<i>trans</i> alkene isomerization step.The Journal of organic chemistry3480-3484https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894645biostudies-literatureRuthenium-Catalyzed Transfer Hydrogenation of Alkynes: Access to Alkanes and (<i>E</i>)- or (<i>Z</i>)-Alkenes in Tandem with Pd/Cu Sonogashira Cross-Coupling.PMC11894645Jankovic DKosmrlj JGazvoda MfalseRuthenium-Catalyzed Transfer Hydrogenation of Alkynes: Access to Alkanes and (<i>E</i>)- or (<i>Z</i>)-Alkenes in Tandem with Pd/Cu Sonogashira Cross-Coupling.A complete reduction of alkynes using a combination of [RuCl<sub>2</sub>(<i>p</i>-cymene)]<sub>2</sub>, DTBM-SEGPHOS, and a paraformaldehyde/water system as the hydrogen source was developed, affording alkanes in 52-99% yields. In addition, the preparation of alkenes from terminal alkynes and aryl iodides by a tandem process of Pd/Cu-catalyzed Sonogashira reaction followed by Ru-catalyzed transfer hydrogenation is reported, affording alkenes in 38-99% yields. This multicatalysis proceeds via three consecutive reactions and can be extended further, as shown by adding an iodine-catalyzed <i>cis</i>-<i>trans</i> alkene isomerization step.2025-01-01T00:00:00Z2025 Mar2025-04-04T01:13:08.072Z2025-04-04T01:13:08.072ZS-EPMC118946454001358610.1021/acs.joc.4c01864