{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scotton WJ"],"funding":["The Wolfson Foundation","University of California, San Francisco, Memory and Aging Center","Brain Research UK","NIA NIH HHS","Medical Research Council Skills Development Fellowship","University College London","Medical Research Council Clinician Scientist Fellowship","Laboratory for Neuro Imaging at the University of Southern California","National Institutes of Health","Cure Parkinson’s Trust","UK Dementia Research Institute Ltd","PSP Association and CBD Solutions","Alzheimer’s Association and the Shenandoah Foundation","Cambridge Centre for Parkinson-plus","UK Dementia Research Institute","Evelyn Trust","UK Research and Innovation Future Leaders Fellow","Rainwater Charitable Foundation","National Institute for Health and Care Research Rare Disease Translational Research Collaboration","Michael J Fox Foundation","National Institute for Health and Care Research Cambridge Biomedical Research Centre","Leonard Wolfson Experimental Neurology Centre","Clinical Research Facility","University College London Hospitals","Alzheimer’s Association and the Association for Frontotemporal Degeneration","Wellcome Trust Clinical PhD fellowship","National Institute for Health and Care Research Biomedical Research Centre","4-Repeat Tauopathy Neuroimaging Initiative","Dementia Research Institute Ltd","CBD Solutions","National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre","National Institute for Health and Care Research UCLH Biomedical Research Centre","Drake Foundation","Tau Research Consortium","Bluefield Project to Cure FTD","Miriam Marks Brain Research UK Senior Fellowship","Wellcome Trust Investigator in Science Award","Medical Research Council","FTLDNI","Alzheimer's Society","Parkinson’s UK","UK Research and Innovation Medical Research Council","PSP Association","Alzheimer’s Research UK","Wellcome Trust","Rotha Abraham Trust"],"pagination":["fcaf066"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894806"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(2)"],"pubmed_abstract":["Although the corticobasal syndrome was originally most closely linked with the pathology of corticobasal degeneration, the 2013 Armstrong clinical diagnostic criteria, without the addition of aetiology-specific biomarkers, have limited positive predictive value for identifying corticobasal degeneration pathology in life. Autopsy studies demonstrate considerable pathological heterogeneity in corticobasal syndrome, with corticobasal degeneration pathology accounting for only ∼50% of clinically diagnosed individuals. Individualized disease stage and progression modelling of brain changes in corticobasal syndrome may have utility in predicting this underlying pathological heterogeneity, and in turn improve the design of clinical trials for emerging disease-modifying therapies. The aim of this "],"journal":["Brain communications"],"pubmed_title":["Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies."],"pmcid":["PMC11894806"],"funding_grant_id":["NIHR203312","227341/Z/23/Z","AS-JF-19a-004-517","P01AG019724","MR/T027770/1","220258","R01 AG038791","U19AG063911","RF1AG077557","MR/S03546X/1","517","U24AG057437","221915/Z/20/Z","R01AG071756","R01AG038791","MR/T033371/1","ARUK-PG2017-1946","MC_UU_00030/14","R01AG078457","K23 AG073514","MR/M008525/1","004","R01AG073482","R56AG075744","220582/Z/20/Z","K23AG073514","MR/T027800/1","BRC149/NS/MH"],"pubmed_authors":["Shand C","4RTNI Consortium","Jabbari E","Kobylecki C","Toga AW","Hu MTM","Huey ED","Young AL","Litvan I","Irwin DJ","Jensen MT","Alexander D","Bocchetta M","Boxer AL","Boeve BF","Leigh PN","Houlden H","Todd EG","Rohrer JD","Wijeratne PA","Baker SL","VandeVrede L","Tartaglia CM","Scotton WJ","Rowe JB","Fagan A","Fumi R","Oxtoby N","Dickerson BC","Grossman M","Vaughan DP","Lux D","Quaegebeur A","PROSPECT Consortium","Pantelyat A","Cash DM","Morris HR","Heuer HW"],"additional_accession":[]},"is_claimable":false,"name":"Distinct spatiotemporal atrophy patterns in corticobasal syndrome are associated with different underlying pathologies.","description":"Although the corticobasal syndrome was originally most closely linked with the pathology of corticobasal degeneration, the 2013 Armstrong clinical diagnostic criteria, without the addition of aetiology-specific biomarkers, have limited positive predictive value for identifying corticobasal degeneration pathology in life. Autopsy studies demonstrate considerable pathological heterogeneity in corticobasal syndrome, with corticobasal degeneration pathology accounting for only ∼50% of clinically diagnosed individuals. Individualized disease stage and progression modelling of brain changes in corticobasal syndrome may have utility in predicting this underlying pathological heterogeneity, and in turn improve the design of clinical trials for emerging disease-modifying therapies. The aim of this ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T12:53:00.209Z","creation":"2025-04-04T13:11:05.467Z"},"accession":"S-EPMC11894806","cross_references":{"pubmed":["40070441"],"doi":["10.1093/braincomms/fcaf066"]}}