biostudies-literatureUnknown112(3)EuroSurg Collaborative and STARSurg Collaborative<h4>Background</h4>There is low-certainty evidence on the impact of extended pharmacological prophylaxis on venous thromboembolism-associated morbidity and mortality. The aim of this study was to determine the efficacy and safety of extended prophylaxis after major abdominopelvic surgery for the prevention of clinically relevant venous thromboembolism after hospital discharge.<h4>Methods</h4>CArdiovaSCulAr outcomes after major abDominal surgEry (CASCADE) was a prospective, international, cohort study into which consecutive adult patients undergoing major abdominopelvic surgery were enrolled (January-May 2022). Extended prophylaxis was considered at least 28 days of anticoagulant prescription after surgery. The primary efficacy outcome was clinically relevant venous thromboembolism and the The British journal of surgeryznaf005https://www.ebi.ac.uk/biostudies/studies/S-EPMC11894929biostudies-literatureExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.PMC11894929Nieto-Sanchez MFlanagan JRizk CAguzzoli LKeelan SThornton WQuagli OJeremic KMorinelli VSantos RFBaloch LGFound PDe Lisa AMccormac-Prekeze MSoytas MKovacic RAkgun ZEOzkal IBucurica ASchulz RThornton JBridgewater SMustafa HLaseca MDuque Mallen VKozadinos AZahlmann NZachomitros FGaspar DFancellu APolat SSeeva Balan SBeazer TMansi MCastanheira Rodrigues SScardino AYavuz Akca TBirkenhead PStamopoulos PBarros MO'reilly CGaspar SShomoye DVillota Tamayo BO'reilly AAljobbeh MGravas SGiambra MMBarba MLunca SFornasiero MMolasy BLeonidou MFernandes Dos Santos JPKanesan HPapanikolaou ESales FCicek 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extended pharmacological prophylaxis on venous thromboembolism-associated morbidity and mortality. The aim of this study was to determine the efficacy and safety of extended prophylaxis after major abdominopelvic surgery for the prevention of clinically relevant venous thromboembolism after hospital discharge.<h4>Methods</h4>CArdiovaSCulAr outcomes after major abDominal surgEry (CASCADE) was a prospective, international, cohort study into which consecutive adult patients undergoing major abdominopelvic surgery were enrolled (January-May 2022). Extended prophylaxis was considered at least 28 days of anticoagulant prescription after surgery. The primary efficacy outcome was clinically relevant venous thromboembolism and the 2025-01-01T00:00:00Z2025 Mar2025-04-20T01:46:24.245Z2025-04-20T01:46:24.245ZS-EPMC118949294006719210.1093/bjs/znaf005