biostudies-literatureUnknown6(2)Zhai WThe rapid spread of mobile tigecycline resistance presents a significant public health threat, particularly with the increasing prevalence of <i>tet</i>(X4)-positive Enterobacterales across various species. This study aimed to investigate the epidemic features and transmission dynamics of <i>tet</i>(X4)-positive <i>Klebsiella pneumoniae</i> (<i>K</i>. <i>pneumoniae</i>) through the analysis of 206 raw meats, including pork (<i>n</i> = 182), beef (<i>n</i> = 16), duck (<i>n</i> = 5), and chicken (<i>n</i> = 3). These samples were collected from schools, markets, and restaurants in Chengdu City, China. A total of 25 isolates were obtained from 13 administrative regions. All isolates exhibited resistance to tetracycline, tigecycline, ampicillin, chloramphenicol, and florfenicol. Over half of Biosafety and health116-124https://www.ebi.ac.uk/biostudies/studies/S-EPMC11895030biostudies-literatureEpidemiology and genetic characterization of <i>tet</i>(X4)-positive <i>Klebsiella pneumoniae</i> and <i>Klebsiella quasipneumoniae</i> isolated from raw meat in Chengdu City, China.PMC11895030Fu BShen JZhai WWu CWang YSun HLiu DZhang QfalseEpidemiology and genetic characterization of <i>tet</i>(X4)-positive <i>Klebsiella pneumoniae</i> and <i>Klebsiella quasipneumoniae</i> isolated from raw meat in Chengdu City, China.The rapid spread of mobile tigecycline resistance presents a significant public health threat, particularly with the increasing prevalence of <i>tet</i>(X4)-positive Enterobacterales across various species. This study aimed to investigate the epidemic features and transmission dynamics of <i>tet</i>(X4)-positive <i>Klebsiella pneumoniae</i> (<i>K</i>. <i>pneumoniae</i>) through the analysis of 206 raw meats, including pork (<i>n</i> = 182), beef (<i>n</i> = 16), duck (<i>n</i> = 5), and chicken (<i>n</i> = 3). These samples were collected from schools, markets, and restaurants in Chengdu City, China. A total of 25 isolates were obtained from 13 administrative regions. All isolates exhibited resistance to tetracycline, tigecycline, ampicillin, chloramphenicol, and florfenicol. Over half of 2024-01-01T00:00:00Z2024 Apr2026-06-03T04:43:17.177Z2025-04-06T22:14:07.831ZS-EPMC118950304007894510.1016/j.bsheal.2024.02.004