biostudies-literatureYe SWNational Natural Science Foundation of ChinaThe National Key R&D Program of ChinaNIH HHSe14411https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896485biostudies-literatureUnknown24(3)The risk of many human diseases including cardiovascular diseases, cancer, neurodegenerative diseases, and musculoskeletal disorders rises significantly in the elderly. With the increase in the aging population, it is becoming increasingly important to understand the biology of healthy aging and develop interventions that slow down the aging process or prevent age-related diseases. In this study, by a high-throughput screen in Caenorhabditis elegans (C. elegans), we identified 11 small molecules that promote healthy aging. Among them, Carbamazepine (a voltage-gated channels inhibitor) and Calmagite (a calcium and magnesium indicator) enhanced serotonin (5-HT) and dopamine (DA) levels, extended lifespan, and preserved several important behaviors in aging C. elegans. These behaviors include Aging cellA small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway.PMC118964852023YFC36034002023YFC36033008233004731925022P40 OD010440Song SDLiu XJCai SQLuo YYe SWfalseA small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway.The risk of many human diseases including cardiovascular diseases, cancer, neurodegenerative diseases, and musculoskeletal disorders rises significantly in the elderly. With the increase in the aging population, it is becoming increasingly important to understand the biology of healthy aging and develop interventions that slow down the aging process or prevent age-related diseases. In this study, by a high-throughput screen in Caenorhabditis elegans (C. elegans), we identified 11 small molecules that promote healthy aging. Among them, Carbamazepine (a voltage-gated channels inhibitor) and Calmagite (a calcium and magnesium indicator) enhanced serotonin (5-HT) and dopamine (DA) levels, extended lifespan, and preserved several important behaviors in aging C. elegans. These behaviors include 2025-01-01T00:00:00Z2025 Mar2025-04-06T22:39:21.315Z2025-04-04T02:54:19.556ZS-EPMC118964853955254010.1111/acel.14411