{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Conway J"],"funding":["British Heart Foundation","Academy of Medical Sciences Springboard Award","MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research. GA is supported by an MRC Programme Grant"],"pagination":["e14401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896561"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a feature of ageing linked to declining health, and increased intestinal membrane permeability has been shown to promote heightened systemic inflammation in aged hosts. Concurrent with age-related changes in the gut microbiome, the thymic microenvironment undergoes a series of morphological, phenotypical and architectural alterations with age, including disorganisation of the corticomedullary junction, increased fibrosis, increased thymic adiposity and the accumulation of senescent cells. However, a direct link between gut barrier dysbiosis and thy"],"journal":["Aging cell"],"pubmed_title":["Age-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing."],"pmcid":["PMC11896561"],"funding_grant_id":["SBF0051132","MR/T029765/1"],"pubmed_authors":["Dugan B","Conway J","Bowdish DME","Sharma-Oates A","Sullivan J","White AJ","Mauro C","van Schaik W","Lamberte LE","Parnell SM","Duggal NA","De Jong EN","Anderson G","Rees NP"],"additional_accession":[]},"is_claimable":false,"name":"Age-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing.","description":"The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a feature of ageing linked to declining health, and increased intestinal membrane permeability has been shown to promote heightened systemic inflammation in aged hosts. Concurrent with age-related changes in the gut microbiome, the thymic microenvironment undergoes a series of morphological, phenotypical and architectural alterations with age, including disorganisation of the corticomedullary junction, increased fibrosis, increased thymic adiposity and the accumulation of senescent cells. However, a direct link between gut barrier dysbiosis and thy","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-26T02:45:28.274Z","creation":"2025-04-06T10:34:01.797Z"},"accession":"S-EPMC11896561","cross_references":{"pubmed":["39547946"],"doi":["10.1111/acel.14401"]}}