biostudies-literatureConway JBritish Heart FoundationAcademy of Medical Sciences Springboard AwardMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research. GA is supported by an MRC Programme Grante14401https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896561biostudies-literatureUnknown24(3)The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a feature of ageing linked to declining health, and increased intestinal membrane permeability has been shown to promote heightened systemic inflammation in aged hosts. Concurrent with age-related changes in the gut microbiome, the thymic microenvironment undergoes a series of morphological, phenotypical and architectural alterations with age, including disorganisation of the corticomedullary junction, increased fibrosis, increased thymic adiposity and the accumulation of senescent cells. However, a direct link between gut barrier dysbiosis and thyAging cellAge-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing.PMC11896561SBF0051132MR/T029765/1Dugan BConway JBowdish DMESharma-Oates ASullivan JWhite AJMauro Cvan Schaik WLamberte LEParnell SMDuggal NADe Jong ENAnderson GRees NPfalseAge-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing.The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a feature of ageing linked to declining health, and increased intestinal membrane permeability has been shown to promote heightened systemic inflammation in aged hosts. Concurrent with age-related changes in the gut microbiome, the thymic microenvironment undergoes a series of morphological, phenotypical and architectural alterations with age, including disorganisation of the corticomedullary junction, increased fibrosis, increased thymic adiposity and the accumulation of senescent cells. However, a direct link between gut barrier dysbiosis and thy2025-01-01T00:00:00Z2025 Mar2025-04-26T02:45:28.274Z2025-04-06T10:34:01.797ZS-EPMC118965613954794610.1111/acel.14401