{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Czaran D"],"pubmed_abstract":["<h4>Objective</h4>Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes. Our group previously demonstrated that the leukocyte-specific GTPase-activating protein ARHGAP25 regulates phagocyte effector functions and is crucial in the pathomechanism of autoantibody-induced arthritis. Here, we investigate its role in the pathogenesis of the more complex inflammatory process of contact hyperse"],"journal":["Frontiers in immunology"],"pagination":["1509713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896868"],"repository":["biostudies-literature"],"pubmed_title":["ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity."],"pmcid":["PMC11896868"],"pubmed_authors":["Sasvari P","Csepanyi-Komi R","Lorincz K","Ella K","Czaran D","Gellen V"],"additional_accession":[]},"is_claimable":false,"name":"ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity.","description":"<h4>Objective</h4>Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes. Our group previously demonstrated that the leukocyte-specific GTPase-activating protein ARHGAP25 regulates phagocyte effector functions and is crucial in the pathomechanism of autoantibody-induced arthritis. Here, we investigate its role in the pathogenesis of the more complex inflammatory process of contact hyperse","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-04T01:41:23.631Z","creation":"2025-04-04T01:41:23.631Z"},"accession":"S-EPMC11896868","cross_references":{"pubmed":["40078992"],"doi":["10.3389/fimmu.2025.1509713"]}}