biostudies-literatureUnknown16Czaran D<h4>Objective</h4>Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes. Our group previously demonstrated that the leukocyte-specific GTPase-activating protein ARHGAP25 regulates phagocyte effector functions and is crucial in the pathomechanism of autoantibody-induced arthritis. Here, we investigate its role in the pathogenesis of the more complex inflammatory process of contact hyperseFrontiers in immunology1509713https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896868biostudies-literatureARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity.PMC11896868Sasvari PCsepanyi-Komi RLorincz KElla KCzaran DGellen VfalseARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity.<h4>Objective</h4>Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes. Our group previously demonstrated that the leukocyte-specific GTPase-activating protein ARHGAP25 regulates phagocyte effector functions and is crucial in the pathomechanism of autoantibody-induced arthritis. Here, we investigate its role in the pathogenesis of the more complex inflammatory process of contact hyperse2025-01-01T00:00:00Z20252025-04-04T01:41:23.631Z2025-04-04T01:41:23.631ZS-EPMC118968684007899210.3389/fimmu.2025.1509713