{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu K"],"funding":["NIDA NIH HHS"],"pagination":["e70267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896887"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(3)"],"pubmed_abstract":["<h4>Background</h4>The HIV-1 reservoir in CD4+ T cells (HR<sub>CD4</sub>) pose a major challenge to curing HIV, with many of its mechanisms still unclear. HIV-1 DNA integration and immune responses may alter the host's epigenetic landscape, potentially silencing HIV-1 replication.<h4>Methods</h4>This study used bisulphite capture DNA methylation sequencing in CD4+ T cells from the blood of 427 virally suppressed women with HIV to identify differentially methylated sites and regions associated with HR<sub>CD4</sub>.<h4>Results</h4>The average total HR<sub>CD4</sub> size was 1409 copies per million cells, with most proviruses defective and only a small proportion intact. The study identified 245 differentially methylated CpG sites and 85 regions linked to HR<sub>CD4</sub> size, with 52% of s"],"journal":["Clinical and translational medicine"],"pubmed_title":["Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV."],"pmcid":["PMC11896887"],"funding_grant_id":["R01DA047820","R01DA052846","R01DA047063","R01DA061926"],"pubmed_authors":["Xu K","Asam K","Kuniholm MH","Archin NM","Page GP","Valizadeh A","Topper EF","Cohen MH","Aouizerat BE","DeHovitz J","Tien PC","Marconi VC","Zhang X","Johnson EO","Lahiri CD","Martinez C","Hancock DB","Konkle-Parker D","Quach BC","Kassaye SG"],"additional_accession":[]},"is_claimable":false,"name":"Aberrant DNA methylation of genes regulating CD4+ T cell HIV-1 reservoir in women with HIV.","description":"<h4>Background</h4>The HIV-1 reservoir in CD4+ T cells (HR<sub>CD4</sub>) pose a major challenge to curing HIV, with many of its mechanisms still unclear. HIV-1 DNA integration and immune responses may alter the host's epigenetic landscape, potentially silencing HIV-1 replication.<h4>Methods</h4>This study used bisulphite capture DNA methylation sequencing in CD4+ T cells from the blood of 427 virally suppressed women with HIV to identify differentially methylated sites and regions associated with HR<sub>CD4</sub>.<h4>Results</h4>The average total HR<sub>CD4</sub> size was 1409 copies per million cells, with most proviruses defective and only a small proportion intact. The study identified 245 differentially methylated CpG sites and 85 regions linked to HR<sub>CD4</sub> size, with 52% of s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T01:41:24.005Z","creation":"2025-04-04T01:41:24.005Z"},"accession":"S-EPMC11896887","cross_references":{"pubmed":["40070009"],"doi":["10.1002/ctm2.70267"]}}