biostudies-literatureKoch VAgence Nationale de la RechercheDoktor Robert Pfleger-StiftungSiRIC InsiTu: Insights into cancer: From inflammation to tumor1890-1904https://www.ebi.ac.uk/biostudies/studies/S-EPMC11896941biostudies-literatureUnknown61(4)<h4>Background</h4>Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction-associated steatohepatitis.<h4>Purpose</h4>To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acoustic (AC) solution utilizing a 2D-MRE approach. Additionally, quality index markers (QIs) were proposed to identify image pixels with sufficient quality for reliably estimating tissue biomechanics.<h4>Study type</h4>Prospective.<h4>Population</h4>One hundred seventy participants with suspected or confirmed liver disease (median age, 57 years [interquartile range (IQR), 46-65]; 66 females), and 11 healthy volunteers (median age, 31 years [IQR, 27-34]; 5 females).<Journal of magnetic resonance imaging : JMRIBiomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic MR Elastography.PMC11896941INCa-DGOS-INSERM-ITMO Cancer_18008ANR-21-RHUS-0012Finkelmeier FZiegengeist NSCengiz DVogl TJMahmoudi SZeuzem SD'Angelo TPathil-Warth ABooz CHammerstingl RMDahmer IKinzler MNCimprich MAlmansour HEichler KKoch VScholtz JESolim LAGotta JMartin SSBernatz SDarwish OGruenewald LDTorgashov KAnnio GHerrmann EThalhammer AAlizadeh LSOnay MKonrad PChernyak VWild PVilgrain VYel ISinkus RGruber-Rouh TTaylor SAfalseBiomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic MR Elastography.<h4>Background</h4>Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction-associated steatohepatitis.<h4>Purpose</h4>To compare the performance of 2D/3D-MRE using the gravitational (GT) transducer concept with the current commercial acoustic (AC) solution utilizing a 2D-MRE approach. Additionally, quality index markers (QIs) were proposed to identify image pixels with sufficient quality for reliably estimating tissue biomechanics.<h4>Study type</h4>Prospective.<h4>Population</h4>One hundred seventy participants with suspected or confirmed liver disease (median age, 57 years [interquartile range (IQR), 46-65]; 66 females), and 11 healthy volunteers (median age, 31 years [IQR, 27-34]; 5 females).<2025-01-01T00:00:00Z2025 Apr2025-04-04T00:27:35.857Z2025-04-04T00:27:35.857ZS-EPMC118969413916513910.1002/jmri.29560