{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amirrad F"],"funding":["NHLBI NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Heart, Lung, and Blood Institute","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)"],"pagination":["2422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11897200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Progesterone receptors are classified into nuclear and membrane-bound receptor families. Previous unbiased proteomic studies indicate a potential association between cardiac diseases and the progesterone receptor membrane-bound component-2 (PGRMC2); however, the role of PGRMC2 in the heart remains unknown. In this study, we use a heart-specific knockout (KO) mouse model (MyH6•Pgrmc2<sup>flox/flox</sup>) in which the Pgrmc2 gene was selectively deleted in cardiomyocytes. Here we show that PGRMC2 serves as a mediator of steroid hormones for rapid calcium signaling in cardiomyocytes to maintain cardiac contraction, sufficient stroke volume, and adequate cardiac output by regulating the cardiac pressure-volume relationship. The KO hearts from male and female mice exhibit an impairment in press"],"journal":["Nature communications"],"pubmed_title":["PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice."],"pmcid":["PMC11897200"],"funding_grant_id":["R01 HL147311","HL131577"],"pubmed_authors":["Pru JK","La V","Ohadi S","Albotaif M","Shamloo K","Nauli SM","Mohieldin AM","Amirrad F","Webster S"],"additional_accession":[]},"is_claimable":false,"name":"PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice.","description":"Progesterone receptors are classified into nuclear and membrane-bound receptor families. Previous unbiased proteomic studies indicate a potential association between cardiac diseases and the progesterone receptor membrane-bound component-2 (PGRMC2); however, the role of PGRMC2 in the heart remains unknown. In this study, we use a heart-specific knockout (KO) mouse model (MyH6•Pgrmc2<sup>flox/flox</sup>) in which the Pgrmc2 gene was selectively deleted in cardiomyocytes. Here we show that PGRMC2 serves as a mediator of steroid hormones for rapid calcium signaling in cardiomyocytes to maintain cardiac contraction, sufficient stroke volume, and adequate cardiac output by regulating the cardiac pressure-volume relationship. The KO hearts from male and female mice exhibit an impairment in press","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-05-29T19:11:01.501Z","creation":"2025-04-04T01:28:22.541Z"},"accession":"S-EPMC11897200","cross_references":{"pubmed":["40069180"],"doi":["10.1038/s41467-025-57707-8"]}}