{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rong J"],"funding":["Open Project of Key Laboratory of Longevity and Aging-related Diseases(Guangxi Medical University), Ministry of Education","the Guangxi Natural Science Foundation for Innovation Research Team","The study was supported by the Major Science and Technology Projects in Guangxi","Innovation Platform and Talent Plan in Guilin","Xinghu Scholars Program of Guangxi Medical University，the Open Project Program of Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University","he National Natural Science Foundation of China","the National Natural Science Foundation of China"],"pagination":["8387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11897380"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations. In the 30-59 age group, the overall metal mixture was significantly negatively associated with rTL (estimate = -0.069, P = 0.003), with Zn as the dominant contributor. In the elderly, the metal mixture was positively associated with rTL (estimate = 0.040, P = 0.031), with Cr and Mn as main contributors. The findings highlight the importance of maintaining adequate Cr and Mn levels in older "],"journal":["Scientific reports"],"pubmed_title":["Associations of essential trace metals with telomere length in general population: a cross-sectional study."],"pmcid":["PMC11897380"],"funding_grant_id":["KLLAD202304","82260629","81960583","20220120-2","2022-GKLEH-02","2019GXNSFGA245002","AA22096026"],"pubmed_authors":["Jin W","Lu Y","Qin J","Cai J","Liu Q","Guan Q","Teng K","Ye Z","Li Y","Zhang T","Zhao L","Zhang Z","Luo L","Wu S","Rong J"],"additional_accession":[]},"is_claimable":false,"name":"Associations of essential trace metals with telomere length in general population: a cross-sectional study.","description":"This study investigated the relationship between essential plasma metals (Co, Cr, Cu, Mn, Mo, Se, Zn) and telomere length in 2,194 Chinese adults aged ≥ 30 years. Metal concentrations were measured using ICP-MS, and leukocyte relative telomere length (rTL) was assessed by qPCR. In the elderly, Cr and Mn were significantly positively correlated with rTL, while Mo, Zn, and Cu showed negative correlations. In the 30-59 age group, the overall metal mixture was significantly negatively associated with rTL (estimate = -0.069, P = 0.003), with Zn as the dominant contributor. In the elderly, the metal mixture was positively associated with rTL (estimate = 0.040, P = 0.031), with Cr and Mn as main contributors. The findings highlight the importance of maintaining adequate Cr and Mn levels in older ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-03T23:56:45.611Z","creation":"2025-04-03T23:56:45.611Z"},"accession":"S-EPMC11897380","cross_references":{"pubmed":["40069335"],"doi":["10.1038/s41598-025-93216-w"]}}