biostudies-literatureUnknown27Pan JY<h4>Background</h4>A significant number of individuals with depression in Hong Kong remain undiagnosed and untreated through traditional face-to-face psychotherapy. Internet-based cognitive behavioral therapy (iCBT) has emerged as a tool to improve access to mental health services. However, iCBT remains underdeveloped in Chinese communities, particularly in Hong Kong.<h4>Objective</h4>This study aims to (1) develop and evaluate the effectiveness of a culturally and linguistically appropriate guided iCBT program for Hong Kong Chinese with depressive symptoms, and (2) explore their treatment adherence.<h4>Methods</h4>An 11-week guided iCBT program, "Confront and Navigate Depression Online" (CANDO), consisting of 8 online modules, was developed and implemented for Hong Kong residents. The proJournal of medical Internet researche64303https://www.ebi.ac.uk/biostudies/studies/S-EPMC11897664biostudies-literatureCulturally Adapted Guided Internet-Based Cognitive Behavioral Therapy for Hong Kong People With Depressive Symptoms: Randomized Controlled Trial.PMC11897664Rafi JPan JYfalseCulturally Adapted Guided Internet-Based Cognitive Behavioral Therapy for Hong Kong People With Depressive Symptoms: Randomized Controlled Trial.<h4>Background</h4>A significant number of individuals with depression in Hong Kong remain undiagnosed and untreated through traditional face-to-face psychotherapy. Internet-based cognitive behavioral therapy (iCBT) has emerged as a tool to improve access to mental health services. However, iCBT remains underdeveloped in Chinese communities, particularly in Hong Kong.<h4>Objective</h4>This study aims to (1) develop and evaluate the effectiveness of a culturally and linguistically appropriate guided iCBT program for Hong Kong Chinese with depressive symptoms, and (2) explore their treatment adherence.<h4>Methods</h4>An 11-week guided iCBT program, "Confront and Navigate Depression Online" (CANDO), consisting of 8 online modules, was developed and implemented for Hong Kong residents. The pro2025-01-01T00:00:00Z2025 Feb2026-06-01T19:20:24.538Z2025-04-04T09:07:51.727ZS-EPMC118976643999886510.2196/64303