{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van den Dijssel J"],"funding":["University of Melbourne","Australian Research Council","Sanquin Blood Supply Project Grant"],"pagination":["e202451565"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11898545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(3)"],"pubmed_abstract":["Immunosenescence, age-related immune dysregulation, reduces immunity upon vaccinations and infections. Cytomegalovirus (CMV) infection results in declining naïve (T<sub>naïve</sub>) and increasing terminally differentiated (T<sub>emra</sub>) T cell populations, further aggravating immune aging. Both immunosenescence and CMV have been speculated to hamper the formation of protective T-cell immunity against novel or emerging pathogens. The SARS-CoV-2 pandemic presented a unique opportunity to examine the impact of age and/or CMV on the generation of de novo SARS-CoV-2-specific CD8<sup>+</sup> T cell responses in 40 younger (22-40 years) and 37 older (50-66 years) convalescent individuals. Heterotetramer combinatorial coding combined with phenotypic markers were used to study 35 SARS-CoV-2 ep"],"journal":["European journal of immunology"],"pubmed_title":["Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Responses."],"pmcid":["PMC11898545"],"funding_grant_id":["PPOC / L2506","EstablishmentGrant","ARC-DECRA Fellowship / DE220100185"],"pubmed_authors":["van de Sandt CE","Raaphorst H","Turksma AW","Veldhuisen B","van den Dijssel J","Koets L","Ten Brinke A","van Lier RAW","van Ham SM","de Jongh R","Freen-van Heeren JJ","Steenhuis M","Konijn VAL","Duurland MC","van der Schoot CE","van Gisbergen KPJM","Rispens T"],"additional_accession":[]},"is_claimable":false,"name":"Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8&lt;sup&gt;+&lt;/sup&gt; T Cell Responses.","description":"Immunosenescence, age-related immune dysregulation, reduces immunity upon vaccinations and infections. Cytomegalovirus (CMV) infection results in declining naïve (T<sub>naïve</sub>) and increasing terminally differentiated (T<sub>emra</sub>) T cell populations, further aggravating immune aging. Both immunosenescence and CMV have been speculated to hamper the formation of protective T-cell immunity against novel or emerging pathogens. The SARS-CoV-2 pandemic presented a unique opportunity to examine the impact of age and/or CMV on the generation of de novo SARS-CoV-2-specific CD8<sup>+</sup> T cell responses in 40 younger (22-40 years) and 37 older (50-66 years) convalescent individuals. Heterotetramer combinatorial coding combined with phenotypic markers were used to study 35 SARS-CoV-2 ep","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T09:07:36.449Z","creation":"2025-04-04T09:07:36.449Z"},"accession":"S-EPMC11898545","cross_references":{"pubmed":["40071711"],"doi":["10.1002/eji.202451565"]}}