{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng F"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","Deutsche Forschungsgemeinschaft"],"pagination":["e0285924"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11898615"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(3)"],"pubmed_abstract":["Structural maintenance of chromosomes (SMC) are ubiquitously distributed proteins involved in chromosome organization. Deletion of <i>smc</i> causes severe growth phenotypes in many organisms. Surprisingly, <i>smc</i> can be deleted in <i>Corynebacterium glutamicum</i>, a member of the <i>Actinomycetota</i> phylum, without any apparent growth phenotype. SMC in <i>C. glutamicum</i> is loaded in a ParB-dependent fashion to the chromosome and functions in replichore cohesion. The unexpected absence of a growth phenotype in the <i>smc</i> mutant prompted us to screen for synthetic interactions within <i>C. glutamicum</i>. We generated a high-density Tn5 library from wild-type and <i>smc</i>-deleted <i>C. glutamicum</i> strains. Transposon sequencing data revealed that the DNA translocase FtsK "],"journal":["mBio"],"pubmed_title":["Early onset of septal FtsK localization allows for efficient DNA segregation in SMC-deleted &lt;i&gt;Corynebacterium glutamicum&lt;/i&gt; strains."],"pmcid":["PMC11898615"],"funding_grant_id":["INST 257/645-1","BR2815/6-2"],"pubmed_authors":["Linder M","Ruckert-Reed C","Bramkamp M","Haak M","Peng F","Kalinowski J","Meyer F","Weiß M","Giacomelli G"],"additional_accession":[]},"is_claimable":false,"name":"Early onset of septal FtsK localization allows for efficient DNA segregation in SMC-deleted &lt;i&gt;Corynebacterium glutamicum&lt;/i&gt; strains.","description":"Structural maintenance of chromosomes (SMC) are ubiquitously distributed proteins involved in chromosome organization. Deletion of <i>smc</i> causes severe growth phenotypes in many organisms. Surprisingly, <i>smc</i> can be deleted in <i>Corynebacterium glutamicum</i>, a member of the <i>Actinomycetota</i> phylum, without any apparent growth phenotype. SMC in <i>C. glutamicum</i> is loaded in a ParB-dependent fashion to the chromosome and functions in replichore cohesion. The unexpected absence of a growth phenotype in the <i>smc</i> mutant prompted us to screen for synthetic interactions within <i>C. glutamicum</i>. We generated a high-density Tn5 library from wild-type and <i>smc</i>-deleted <i>C. glutamicum</i> strains. Transposon sequencing data revealed that the DNA translocase FtsK ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-03T23:57:36.823Z","creation":"2025-04-03T23:57:36.823Z"},"accession":"S-EPMC11898615","cross_references":{"pubmed":["39873485"],"doi":["10.1128/mbio.02859-24"]}}