{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tanner AR"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NIH HHS"],"pagination":["1904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11900341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(5)"],"pubmed_abstract":["Postnatally, glucagon acutely lowers plasma amino acid (AA) concentrations by stimulating hepatic AA catabolism, but its fetal actions remain unclear. This study tested whether a 2 h fetal glucagon infusion would stimulate hepatic AA catabolism and inhibit placental AA transfer. Late-gestation pregnant sheep (0.9 gestation) underwent surgical, vascular catheterization and received fetal glucagon (<i>n</i> = 8) or vehicle infusions (<i>n</i> = 8) in a crossover design with a 48 h washout period. Nutrient uptake and utilization were assessed during each infusion, and fetal liver and placental tissue were collected post-infusion under hyperglucagonemic (<i>n</i> = 4) or vehicle (<i>n</i> = 4) conditions. Glucagon receptor was identified in fetal hepatocyte and trophoblast cells. Glucagon redu"],"journal":["International journal of molecular sciences"],"pubmed_title":["A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep."],"pmcid":["PMC11900341"],"funding_grant_id":["P30 DK116073","R01HD093701","T32 HD007186","S10OD023553","R01 HD111557","T32HD007186","P30 DK048520","P30-DK116073","S10 OD023553","R01 HD093701","R01HD111557","R01 DK088139","F32 HD116431"],"pubmed_authors":["Wesolowski SR","Cilvik SN","Nguyen MA","Dobrinskikh E","Anthony RV","Rozance PJ","Tanner AR"],"additional_accession":[]},"is_claimable":false,"name":"A Two-Hour Fetal Glucagon Infusion Stimulates Hepatic Catabolism of Amino Acids in Fetal Sheep.","description":"Postnatally, glucagon acutely lowers plasma amino acid (AA) concentrations by stimulating hepatic AA catabolism, but its fetal actions remain unclear. This study tested whether a 2 h fetal glucagon infusion would stimulate hepatic AA catabolism and inhibit placental AA transfer. Late-gestation pregnant sheep (0.9 gestation) underwent surgical, vascular catheterization and received fetal glucagon (<i>n</i> = 8) or vehicle infusions (<i>n</i> = 8) in a crossover design with a 48 h washout period. Nutrient uptake and utilization were assessed during each infusion, and fetal liver and placental tissue were collected post-infusion under hyperglucagonemic (<i>n</i> = 4) or vehicle (<i>n</i> = 4) conditions. Glucagon receptor was identified in fetal hepatocyte and trophoblast cells. Glucagon redu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-03T23:56:51.584Z","creation":"2025-04-03T23:56:51.584Z"},"accession":"S-EPMC11900341","cross_references":{"pubmed":["40076531"],"doi":["10.3390/ijms26051904"]}}