{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(5)"],"submitter":["Wang Z"],"pubmed_abstract":["Understanding the specific role and underlying mechanisms of mitophagy may provide therapeutic benefit to patients with nasopharyngeal carcinoma (NPC). Forkhead box D1 (<i>FOXD1</i>), is overexpressed in NPC. However, its roles in NPC progression and therapy resistance remain largely unknown. NPC tissues displayed increased <i>FOXD1</i> expression compared to paired non-tumor tissues, which correlated with worse overall survival (OS). Upregulation of <i>FOXD1</i> promoted NPC cell proliferation, colony formation, migration, invasion, and impaired sensitivity to GEM by enhancing mitophagy levels. Mechanistically, <i>FOXD1</i> promoted mitophagy in NPC cells by transcriptionally initiating BNIP3 expression. This enhanced mitophagy, in turn, promoted proliferation, invasion, and migration and"],"journal":["International journal of biological sciences"],"pagination":["1894-1913"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11900802"],"repository":["biostudies-literature"],"pubmed_title":["Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma."],"pmcid":["PMC11900802"],"pubmed_authors":["Liu X","Cao K","He D","Xiao M","Zhu Y","Jin Y","Wang Z","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"Targeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.","description":"Understanding the specific role and underlying mechanisms of mitophagy may provide therapeutic benefit to patients with nasopharyngeal carcinoma (NPC). Forkhead box D1 (<i>FOXD1</i>), is overexpressed in NPC. However, its roles in NPC progression and therapy resistance remain largely unknown. NPC tissues displayed increased <i>FOXD1</i> expression compared to paired non-tumor tissues, which correlated with worse overall survival (OS). Upregulation of <i>FOXD1</i> promoted NPC cell proliferation, colony formation, migration, invasion, and impaired sensitivity to GEM by enhancing mitophagy levels. Mechanistically, <i>FOXD1</i> promoted mitophagy in NPC cells by transcriptionally initiating BNIP3 expression. This enhanced mitophagy, in turn, promoted proliferation, invasion, and migration and","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-08T19:48:54.685Z","creation":"2025-04-04T09:07:47.68Z"},"accession":"S-EPMC11900802","cross_references":{"pubmed":["40083705"],"doi":["10.7150/ijbs.101585"]}}