biostudies-literatureUnknown21(5)Wang ZUnderstanding the specific role and underlying mechanisms of mitophagy may provide therapeutic benefit to patients with nasopharyngeal carcinoma (NPC). Forkhead box D1 (<i>FOXD1</i>), is overexpressed in NPC. However, its roles in NPC progression and therapy resistance remain largely unknown. NPC tissues displayed increased <i>FOXD1</i> expression compared to paired non-tumor tissues, which correlated with worse overall survival (OS). Upregulation of <i>FOXD1</i> promoted NPC cell proliferation, colony formation, migration, invasion, and impaired sensitivity to GEM by enhancing mitophagy levels. Mechanistically, <i>FOXD1</i> promoted mitophagy in NPC cells by transcriptionally initiating BNIP3 expression. This enhanced mitophagy, in turn, promoted proliferation, invasion, and migration andInternational journal of biological sciences1894-1913https://www.ebi.ac.uk/biostudies/studies/S-EPMC11900802biostudies-literatureTargeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.PMC11900802Liu XCao KHe DXiao MZhu YJin YWang ZCheng YfalseTargeting ALG3/FOXD1/BNIP3 Axis Prevents Mitophagy and Gemcitabine Resistance of Nasopharyngeal Carcinoma.Understanding the specific role and underlying mechanisms of mitophagy may provide therapeutic benefit to patients with nasopharyngeal carcinoma (NPC). Forkhead box D1 (<i>FOXD1</i>), is overexpressed in NPC. However, its roles in NPC progression and therapy resistance remain largely unknown. NPC tissues displayed increased <i>FOXD1</i> expression compared to paired non-tumor tissues, which correlated with worse overall survival (OS). Upregulation of <i>FOXD1</i> promoted NPC cell proliferation, colony formation, migration, invasion, and impaired sensitivity to GEM by enhancing mitophagy levels. Mechanistically, <i>FOXD1</i> promoted mitophagy in NPC cells by transcriptionally initiating BNIP3 expression. This enhanced mitophagy, in turn, promoted proliferation, invasion, and migration and2025-01-01T00:00:00Z20252026-04-08T19:48:54.685Z2025-04-04T09:07:47.68ZS-EPMC119008024008370510.7150/ijbs.101585