{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Worm A"],"funding":["Emil von Behring und Wilhelm Conrad Röntgen Stiftung","Von Behring-Röntgen-Stiftung"],"pagination":["1594"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11901015"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["<b>Background</b>: Severe strokes often require deep sedation, yet the optimal sedation regimen remains unclear. This comparative study compared the efficacy of achieving target sedation depth using inhaled (isoflurane) versus intravenous (propofol) sedation. <b>Methods</b>: This prospective, observational, proof-of-concept study was conducted between July 2022 and June 2023 at two University Hospitals with dedicated neurological intensive care units. We included conservatively treated patients with severe space-occupying strokes (ischemic or haemorrhagic) requiring deep sedation. Patients received either inhaled or intravenous sedation. Sedation targets were defined in the morning rounds using the Richmond-Agitation-Sedation-Scale and were assessed at two subsequent time points (7 p.m. an"],"journal":["Journal of clinical medicine"],"pubmed_title":["Isoflurane vs. Propofol Sedation in Patients with Severe Stroke: A Clinical Proof-of-Concept-Study."],"pmcid":["PMC11901015"],"funding_grant_id":["69-0031"],"pubmed_authors":["Timmermann L","Diel NJ","Moeller L","Braun SR","Schramm P","Huttner HB","Claudi C","Worm A","Schenker M","Simon OJ","Meyer A","Mrochen A","Juenemann M"],"additional_accession":[]},"is_claimable":false,"name":"Isoflurane vs. Propofol Sedation in Patients with Severe Stroke: A Clinical Proof-of-Concept-Study.","description":"<b>Background</b>: Severe strokes often require deep sedation, yet the optimal sedation regimen remains unclear. This comparative study compared the efficacy of achieving target sedation depth using inhaled (isoflurane) versus intravenous (propofol) sedation. <b>Methods</b>: This prospective, observational, proof-of-concept study was conducted between July 2022 and June 2023 at two University Hospitals with dedicated neurological intensive care units. We included conservatively treated patients with severe space-occupying strokes (ischemic or haemorrhagic) requiring deep sedation. Patients received either inhaled or intravenous sedation. Sedation targets were defined in the morning rounds using the Richmond-Agitation-Sedation-Scale and were assessed at two subsequent time points (7 p.m. an","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-27T03:21:09.536Z","creation":"2025-04-04T09:07:22.013Z"},"accession":"S-EPMC11901015","cross_references":{"pubmed":["40095582"],"doi":["10.3390/jcm14051594"]}}