{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ren S"],"funding":["Science and Technology Innovation Fund of Gansu Agricultural University—Youth Mentor Support Fund","Discipline Team Project of Gansu Agricultural University","National Natural Science Foundation of China","Gansu Province College Teachers Innovation Fund","Key Research and Development Program of Gansu Province","Lanzhou Youth Science and Technology Talent Innovation Project","Li Mingna"],"pagination":["1961"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11901034"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(5)"],"pubmed_abstract":["MiRNAs regulate follicle development and atresia, steroid production, granulosa cell (GC) proliferation, and apoptosis. However, the target genes and the functioning of novel miRNAs remain unexplored. We reveal the targeting relationship between novel-m0297-5p and <i>WNT5A</i> and the specific regulatory mechanism of GC proliferation in small-tailed Han sheep using whole transcriptomic sequencing. We performed whole transcriptomic sequencing on small-tailed Han sheep ovarian GCs supplemented with 10 ng/mL of transforming growth factor-β1 (TGF-β1) during the early stages. This led to identifying the differential expression of novel-m0297-5p and Wnt family member 5A (<i>WNT5A</i>) and predicting their targeting relationship. Based on this, we hypothesized that TGF-β1 could mediate novel-m029"],"journal":["International journal of molecular sciences"],"pubmed_title":["TGF-β1 Mediates Novel-m0297-5p Targeting &lt;i&gt;WNT5A&lt;/i&gt; to Participate in the Proliferation of Ovarian Granulosa Cells in Small-Tailed Han Sheep."],"pmcid":["PMC11901034"],"funding_grant_id":["GAU-QDFC-2024-04","Lanzhou Youth Science and Technology Talent Innovation Project [grant number 2023-QN-187]","The National Natural Science Foundation of China [grant number 31960664]","2023-QN-187","25YFNA029","2025A-083","The Discipline Team Project of Gansu Agricultural University [grant number GAU-XKTD-2022-21]","GAU-XKTD-2022-21","31960664","The Science and Technology Innovation Fund of Gansu Agricultural University - Youth Mentor Support Fund (GAU-QDFC-YYYY-ZZ)"],"pubmed_authors":["Liu Y","Guo Y","Cui J","Ren S","Zhao Z","Wang J","Li M"],"additional_accession":[]},"is_claimable":false,"name":"TGF-β1 Mediates Novel-m0297-5p Targeting &lt;i&gt;WNT5A&lt;/i&gt; to Participate in the Proliferation of Ovarian Granulosa Cells in Small-Tailed Han Sheep.","description":"MiRNAs regulate follicle development and atresia, steroid production, granulosa cell (GC) proliferation, and apoptosis. However, the target genes and the functioning of novel miRNAs remain unexplored. We reveal the targeting relationship between novel-m0297-5p and <i>WNT5A</i> and the specific regulatory mechanism of GC proliferation in small-tailed Han sheep using whole transcriptomic sequencing. We performed whole transcriptomic sequencing on small-tailed Han sheep ovarian GCs supplemented with 10 ng/mL of transforming growth factor-β1 (TGF-β1) during the early stages. This led to identifying the differential expression of novel-m0297-5p and Wnt family member 5A (<i>WNT5A</i>) and predicting their targeting relationship. Based on this, we hypothesized that TGF-β1 could mediate novel-m029","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-28T03:08:52.972Z","creation":"2025-04-03T23:57:21.657Z"},"accession":"S-EPMC11901034","cross_references":{"pubmed":["40076587"],"doi":["10.3390/ijms26051961"]}}