biostudies-literatureUnknown31Kawamoto R<h4>Background</h4>The correlation between serum uric acid/creatinine (SUA/Cr) ratio and hypertension risk has not been well studied. This study aims to examine whether the SUA/Cr ratio is a predictor of hypertension.<h4>Methods</h4>This cohort study comprised 171 men aged 64 ± 11 (mean ± standard deviation) years and 266 women aged 65 ± 10 years recruited for a survey at the community-based annual medical check-up. The main outcome was the presence of hypertension (antihypertensive medication) and having systolic blood pressure (SBP) ≥ 140 mmHg and diastolic blood pressure (DBP) ≥ 90 mmHg.<h4>Results</h4>The baseline SUA/Cr ratio was significantly correlated only with DBP at 3 years in men (<i>r</i> = 0.217, <i>P</i> = 0.004) and women (<i>r</i> = 0.126, <i>P</i> = 0.040), and with both SBP (<i>r</i> = 0.103, <i>P</i> = 0.031) and DBP (<i>r</i> = 0.15, <i>P</i> = 0.001) in the overall participants of men and women. A plausible prognostic cut-off of SUA/Cr ratio (≥ 7.41) was found and was the same in women and in all participants. Multivariable logistic regressions showed that SUA/Cr ratio was significantly linked with hypertension (as a categorical variable, SUA/Cr ratio-2 vs. SUA/Cr ratio-1: odds ratio [OR], 1.68; 95% confidence interval [CI], 0.66-4.30; <i>P</i> = 0.275, SUA/Cr ratio-3 vs. SUA/Cr ratio-1: OR, 2.86; 95% CI, 1.08-7.60; <i>P</i> = 0.035, SUA/Cr ratio-4 vs. SUA/Cr ratio ratio-1: OR, 4.05; 95% CI, 1.32-12.5; <i>P</i> = 0.031, and SUA/Cr ratio ≥ 7.41 vs. SUA/Cr ratio < 7.41: OR, 2.25; 95% CI, 1.32-3.84; <i>P</i> = 0.003). Significant ORs were found for age < 65 years, women, and BMI <25 kg/m², but no interactions were identified within each group.<h4>Conclusions</h4>These results suggest that the baseline SUA/Cr ratio could be an important predictor for the incidence of hypertension in Japanese community-dwelling persons.Clinical hypertensione9https://www.ebi.ac.uk/biostudies/studies/S-EPMC11903210biostudies-literatureHigh serum uric acid/creatinine ratio is a useful predictor of hypertension among Japanese community-dwelling persons.PMC11903210Asuka KKawamoto RNinomiya DAbe MKumagi TfalseHigh serum uric acid/creatinine ratio is a useful predictor of hypertension among Japanese community-dwelling persons.<h4>Background</h4>The correlation between serum uric acid/creatinine (SUA/Cr) ratio and hypertension risk has not been well studied. This study aims to examine whether the SUA/Cr ratio is a predictor of hypertension.<h4>Methods</h4>This cohort study comprised 171 men aged 64 ± 11 (mean ± standard deviation) years and 266 women aged 65 ± 10 years recruited for a survey at the community-based annual medical check-up. The main outcome was the presence of hypertension (antihypertensive medication) and having systolic blood pressure (SBP) ≥ 140 mmHg and diastolic blood pressure (DBP) ≥ 90 mmHg.<h4>Results</h4>The baseline SUA/Cr ratio was significantly correlated only with DBP at 3 years in men (<i>r</i> = 0.217, <i>P</i> = 0.004) and women (<i>r</i> = 0.126, <i>P</i> = 0.040), and with both SBP (<i>r</i> = 0.103, <i>P</i> = 0.031) and DBP (<i>r</i> = 0.15, <i>P</i> = 0.001) in the overall participants of men and women. A plausible prognostic cut-off of SUA/Cr ratio (≥ 7.41) was found and was the same in women and in all participants. Multivariable logistic regressions showed that SUA/Cr ratio was significantly linked with hypertension (as a categorical variable, SUA/Cr ratio-2 vs. SUA/Cr ratio-1: odds ratio [OR], 1.68; 95% confidence interval [CI], 0.66-4.30; <i>P</i> = 0.275, SUA/Cr ratio-3 vs. SUA/Cr ratio-1: OR, 2.86; 95% CI, 1.08-7.60; <i>P</i> = 0.035, SUA/Cr ratio-4 vs. SUA/Cr ratio ratio-1: OR, 4.05; 95% CI, 1.32-12.5; <i>P</i> = 0.031, and SUA/Cr ratio ≥ 7.41 vs. SUA/Cr ratio < 7.41: OR, 2.25; 95% CI, 1.32-3.84; <i>P</i> = 0.003). Significant ORs were found for age < 65 years, women, and BMI <25 kg/m², but no interactions were identified within each group.<h4>Conclusions</h4>These results suggest that the baseline SUA/Cr ratio could be an important predictor for the incidence of hypertension in Japanese community-dwelling persons.2025-01-01T00:00:00Z20252025-04-04T01:29:04.436Z2025-04-04T01:29:04.436ZS-EPMC119032104008359710.5646/ch.2025.31.e9