biostudies-literatureWeiller CDeutsche ForschungsgemeinschaftNIMH NIH HHSbhaf035https://www.ebi.ac.uk/biostudies/studies/S-EPMC11903256biostudies-literatureUnknown35(3)We must reconcile the needs of the internal world and the demands of the external world to make decisions relevant to homeostasis, well-being, and flexible behavior. Engagement with the internal (eg interoceptive) world is linked to medial brain systems, whereas the extrapersonal space (eg exteroceptive) is associated with lateral brain systems. Using Human Connectome Project data, we found three association tracts connecting the action-related frontal lobe with perception-related posterior lobes. A lateral dorsal tract and a medial dorsal tract interact independently with a ventral tract at frontal and posterior hubs. The two frontal and the two posterior hubs are interconnected, forming a meta-loop that integrates lateral and medial brain systems. The four anatomical hubs correspond to tCerebral cortex (New York, N.Y. : 1991)Hubs and interaction: the brain's meta-loop.PMC11903256RE 2740/4-1 (CW)U54 MH091657Hosp JReisert MLevan PRijntjes MWeiller CCoenen VAfalseHubs and interaction: the brain's meta-loop.We must reconcile the needs of the internal world and the demands of the external world to make decisions relevant to homeostasis, well-being, and flexible behavior. Engagement with the internal (eg interoceptive) world is linked to medial brain systems, whereas the extrapersonal space (eg exteroceptive) is associated with lateral brain systems. Using Human Connectome Project data, we found three association tracts connecting the action-related frontal lobe with perception-related posterior lobes. A lateral dorsal tract and a medial dorsal tract interact independently with a ventral tract at frontal and posterior hubs. The two frontal and the two posterior hubs are interconnected, forming a meta-loop that integrates lateral and medial brain systems. The four anatomical hubs correspond to t2025-01-01T00:00:00Z2025 Mar2025-04-03T23:57:05.201Z2025-04-03T23:57:05.201ZS-EPMC119032564007791610.1093/cercor/bhaf035