{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu L"],"funding":["Natural Science Foundation of Zhejiang Province","National Natural Science Foundation of China"],"pagination":["e70318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11903326"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(3)"],"pubmed_abstract":["<h4>Background and purpose</h4>Current guidelines for acute ischemic stroke (AIS) treatment recommend a lenient upper blood pressure (BP) threshold of 185/110 mmHg. However, stricter BP control has been reported to improve prognosis. This study aims to identify the optimal BP range following thrombolysis.<h4>Methods</h4>This observational study included 340 AIS patients treated with rt-PA thrombolysis at the First Affiliated Hospital of Wenzhou Medical University from December 2017 to December 2021. BP levels 24 h after thrombolysis were analyzed to determine their association with clinical outcomes. BP parameters included mean BP, variability (standard deviation (SD)), and decreased magnitudes. The primary outcome was the 90-day modified Rankin Scale (mRS) scores.<h4>Results</h4>Higher me"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Association of Early Blood Pressure Levels and Outcomes in Ischemic Stroke Treated With Intravenous Thrombolysis: A Prospective Cohort Study."],"pmcid":["PMC11903326"],"funding_grant_id":["ZCLY24H0903","81901273"],"pubmed_authors":["Deng B","Li Y","Pang C","Zhang J","Zhu L","Xie J","Gao L","Chen Y","Xie Q","Yu H","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Association of Early Blood Pressure Levels and Outcomes in Ischemic Stroke Treated With Intravenous Thrombolysis: A Prospective Cohort Study.","description":"<h4>Background and purpose</h4>Current guidelines for acute ischemic stroke (AIS) treatment recommend a lenient upper blood pressure (BP) threshold of 185/110 mmHg. However, stricter BP control has been reported to improve prognosis. This study aims to identify the optimal BP range following thrombolysis.<h4>Methods</h4>This observational study included 340 AIS patients treated with rt-PA thrombolysis at the First Affiliated Hospital of Wenzhou Medical University from December 2017 to December 2021. BP levels 24 h after thrombolysis were analyzed to determine their association with clinical outcomes. BP parameters included mean BP, variability (standard deviation (SD)), and decreased magnitudes. The primary outcome was the 90-day modified Rankin Scale (mRS) scores.<h4>Results</h4>Higher me","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T01:28:25.924Z","creation":"2025-04-04T01:28:25.924Z"},"accession":"S-EPMC11903326","cross_references":{"pubmed":["40077828"],"doi":["10.1111/cns.70318"]}}